TY - JOUR
T1 - Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity
AU - Eckel, Robert H.
AU - Depner, Christopher M.
AU - Perreault, Leigh
AU - Markwald, Rachel R.
AU - Smith, Mark R.
AU - McHill, Andrew W.
AU - Higgins, Janine
AU - Melanson, Edward L.
AU - Wright, Kenneth P.
N1 - Funding Information:
R.H.E, has nothing to disclose; C.M.D. has nothing to disclose; L.P. reports personal fees from Merck, personal fees from Bayer, personal fees from Liposcience, personal fees from Boehringer-Ingelheim, and personal fees from Novo Nordisk outside the submitted work; R.R.M. has nothing to disclose; M.R.S. has nothing to disclose; A.W.M. has nothing to disclose; J.H. has nothing to disclose; E.L.M. reports grants from Philips outside the submitted work; K.P.W. reports grants from the NIH during the conduct of the study, personal fees from Zeo, personal fees from Associated Professional Sleep Societies, personal fees from Northwestern University/American Waterways Operators, personal fees from Takeda Global Research and Development, personal fees from American College of Chest Physicians, personal fees from Torvec, and grants from Philips outside the submitted work.
Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2015/11/16
Y1 - 2015/11/16
N2 - Short sleep duration and circadian misalignment are hypothesized to causally contribute to health problems including obesity, diabetes, metabolic syndrome, heart disease, mood disorders, cognitive impairment, and accidents [1-7]. Here, we investigated the influence of morning circadian misalignment induced by an imposed short nighttime sleep schedule on impaired insulin sensitivity, a precursor to diabetes. Imposed short sleep duration resulted in morning wakefulness occurring during the biological night (i.e., circadian misalignment) - a time when endogenous melatonin levels were still high indicating the internal circadian clock was still promoting sleep and related functions. We show the longer melatonin levels remained high after wake time, insulin sensitivity worsened. Overall, we find a simulated 5-day work week of 5-hr-per-night sleep opportunities and ad libitum food intake resulted in ∼20% reduced oral and intravenous insulin sensitivity in otherwise healthy men and women. Reduced insulin sensitivity was compensated by an increased insulin response to glucose, which may reflect an initial physiological adaptation to maintain normal blood sugar [8] levels during sleep loss. Furthermore, we find that transitioning from the imposed short sleep schedule to 9-hr sleep opportunities for 3 days restored oral insulin sensitivity to baseline, but 5 days with 9-hr sleep opportunities was insufficient to restore intravenous insulin sensitivity to baseline. These findings indicate morning wakefulness and eating during the biological night is a novel mechanism by which short sleep duration contributes to metabolic dysregulation and suggests food intake during the biological night may contribute to other health problems associated with short sleep duration.
AB - Short sleep duration and circadian misalignment are hypothesized to causally contribute to health problems including obesity, diabetes, metabolic syndrome, heart disease, mood disorders, cognitive impairment, and accidents [1-7]. Here, we investigated the influence of morning circadian misalignment induced by an imposed short nighttime sleep schedule on impaired insulin sensitivity, a precursor to diabetes. Imposed short sleep duration resulted in morning wakefulness occurring during the biological night (i.e., circadian misalignment) - a time when endogenous melatonin levels were still high indicating the internal circadian clock was still promoting sleep and related functions. We show the longer melatonin levels remained high after wake time, insulin sensitivity worsened. Overall, we find a simulated 5-day work week of 5-hr-per-night sleep opportunities and ad libitum food intake resulted in ∼20% reduced oral and intravenous insulin sensitivity in otherwise healthy men and women. Reduced insulin sensitivity was compensated by an increased insulin response to glucose, which may reflect an initial physiological adaptation to maintain normal blood sugar [8] levels during sleep loss. Furthermore, we find that transitioning from the imposed short sleep schedule to 9-hr sleep opportunities for 3 days restored oral insulin sensitivity to baseline, but 5 days with 9-hr sleep opportunities was insufficient to restore intravenous insulin sensitivity to baseline. These findings indicate morning wakefulness and eating during the biological night is a novel mechanism by which short sleep duration contributes to metabolic dysregulation and suggests food intake during the biological night may contribute to other health problems associated with short sleep duration.
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U2 - 10.1016/j.cub.2015.10.011
DO - 10.1016/j.cub.2015.10.011
M3 - Article
C2 - 26549253
AN - SCOPUS:84959235283
VL - 25
SP - 3004
EP - 3010
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 22
ER -