Mood and anxiety fluctuation in Parkinson's disease associated with levodopa infusion: Preliminary findings

Robert A. Maricle, John G. Nutt, Julie H. Carter

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Pilot data on mood and anxiety changes in 15 Parkinson's disease patients with motor fluctuations are described based on ratings every 30 min for 5 h bracketing a 2‐h constant‐rate levodopa infusion. Robust mood and anxiety effects slightly preceded but temporally paralleled fluctuations in motor tapping scores. Research nurse ratings blind to patient ratings corroborated the changes. The magnitude of changes in mood and anxiety scores did not correlate with the magnitude of changes in tapping scores. The findings of this uncontrolled study suggest mood and anxiety fluctuations may be a common and potentially important component of levodopa‐induced fluctuation.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalMovement Disorders
Volume10
Issue number3
DOIs
StatePublished - May 1995

Keywords

  • Anxiety
  • Depressive disorder
  • Levodopa
  • Mood fluctuations
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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