Monte Carlo modeling of pigmented lesions

Daniel Gareau, Steven Jacques, James Krueger

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Colors observed in clinical dermoscopy are critical to diagnosis but the mechanisms that lead to the spectral components of diffuse reflectance are more than meets the eye: combinations of the absorption and scattering spectra of the biomolecules as well as the a structural effect of skin anatomy. We modeled diffuse remittance from skin based on histopathology. The optical properties of the tissue types were based on the relevant chromophores and scatterers. The resulting spectral images mimic the appearance of pigmented lesions quite well when the morphology is mathematically derived but limited when based on histopathology, raising interesting questions about the interaction between various wavelengths with various pathological anatomical features.

Original languageEnglish (US)
Title of host publicationPhotonic Therapeutics and Diagnostics X
PublisherSPIE
ISBN (Print)9780819498397
DOIs
StatePublished - Jan 1 2014
EventPhotonic Therapeutics and Diagnostics X - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8926
ISSN (Print)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics X
CountryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Gareau, D., Jacques, S., & Krueger, J. (2014). Monte Carlo modeling of pigmented lesions. In Photonic Therapeutics and Diagnostics X [89260V] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8926). SPIE. https://doi.org/10.1117/12.2040473