Monosynaptic excitation of dorsal medullary respiratory neurons by slowly adapting pulmonary stretch receptors

D. B. Averill, William Cameron, A. J. Berger

Research output: Contribution to journalArticle

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Abstract

1. The discharges of individual slowly adapting pulmonary stretch receptors (PSRs) and single respiratory neurons of the dorsal respiratory group (DRG) within the ventrolateral subnucleus of the solitary tract were recorded simultaneously in anesthetized, paralyzed, artificially ventilated cats. 2. DRG neurons were classified as P-cell, I-α, or I-β, based on the alteration in activity during respiratory cycles when lung inflation was withheld compared to activity when the lungs were inflated in phase with central inspiratory drive. In some cases, vagal stimulation was also used to classify respiratory neurons. 3. Synaptic input of PSRs onto DRG neurons was examined by the construction of cross-correlograms for the simultaneously recorded discharge of individual PSRs (reference events) and individual DRG neurons (correlated events). 4. Monosynaptic excitatory connections were demonstrated by peaks in 26% of the cross-correlograms of PSR and P-cell pairs and 20% of the cross-correlograms of PSR and I-β neuron pairs. The ratio of the peak number of occurrences to the background number of occurrences (k value) was comparable for P-cell and I-β neurons: 2.96 ± 2.09 and 1.62 ± 0.36 (mean ± SD), respectively, P-cells and I-β neurons also had similar short latencies for the peak of increased probability of discharge: 2.74 ± 0.53 and 2.57 ± 0.63 ms, respectively. 5. No evidence was obtained demonstrating synaptic connectivity between PSRs and I-α neurons. Interpretations of this negative result are discussed.

Original languageEnglish (US)
Pages (from-to)771-785
Number of pages15
JournalJournal of Neurophysiology
Volume52
Issue number4
StatePublished - 1984
Externally publishedYes

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Pulmonary Stretch Receptors
Neurons
Lung
Economic Inflation
Cats

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Monosynaptic excitation of dorsal medullary respiratory neurons by slowly adapting pulmonary stretch receptors. / Averill, D. B.; Cameron, William; Berger, A. J.

In: Journal of Neurophysiology, Vol. 52, No. 4, 1984, p. 771-785.

Research output: Contribution to journalArticle

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abstract = "1. The discharges of individual slowly adapting pulmonary stretch receptors (PSRs) and single respiratory neurons of the dorsal respiratory group (DRG) within the ventrolateral subnucleus of the solitary tract were recorded simultaneously in anesthetized, paralyzed, artificially ventilated cats. 2. DRG neurons were classified as P-cell, I-α, or I-β, based on the alteration in activity during respiratory cycles when lung inflation was withheld compared to activity when the lungs were inflated in phase with central inspiratory drive. In some cases, vagal stimulation was also used to classify respiratory neurons. 3. Synaptic input of PSRs onto DRG neurons was examined by the construction of cross-correlograms for the simultaneously recorded discharge of individual PSRs (reference events) and individual DRG neurons (correlated events). 4. Monosynaptic excitatory connections were demonstrated by peaks in 26{\%} of the cross-correlograms of PSR and P-cell pairs and 20{\%} of the cross-correlograms of PSR and I-β neuron pairs. The ratio of the peak number of occurrences to the background number of occurrences (k value) was comparable for P-cell and I-β neurons: 2.96 ± 2.09 and 1.62 ± 0.36 (mean ± SD), respectively, P-cells and I-β neurons also had similar short latencies for the peak of increased probability of discharge: 2.74 ± 0.53 and 2.57 ± 0.63 ms, respectively. 5. No evidence was obtained demonstrating synaptic connectivity between PSRs and I-α neurons. Interpretations of this negative result are discussed.",
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N2 - 1. The discharges of individual slowly adapting pulmonary stretch receptors (PSRs) and single respiratory neurons of the dorsal respiratory group (DRG) within the ventrolateral subnucleus of the solitary tract were recorded simultaneously in anesthetized, paralyzed, artificially ventilated cats. 2. DRG neurons were classified as P-cell, I-α, or I-β, based on the alteration in activity during respiratory cycles when lung inflation was withheld compared to activity when the lungs were inflated in phase with central inspiratory drive. In some cases, vagal stimulation was also used to classify respiratory neurons. 3. Synaptic input of PSRs onto DRG neurons was examined by the construction of cross-correlograms for the simultaneously recorded discharge of individual PSRs (reference events) and individual DRG neurons (correlated events). 4. Monosynaptic excitatory connections were demonstrated by peaks in 26% of the cross-correlograms of PSR and P-cell pairs and 20% of the cross-correlograms of PSR and I-β neuron pairs. The ratio of the peak number of occurrences to the background number of occurrences (k value) was comparable for P-cell and I-β neurons: 2.96 ± 2.09 and 1.62 ± 0.36 (mean ± SD), respectively, P-cells and I-β neurons also had similar short latencies for the peak of increased probability of discharge: 2.74 ± 0.53 and 2.57 ± 0.63 ms, respectively. 5. No evidence was obtained demonstrating synaptic connectivity between PSRs and I-α neurons. Interpretations of this negative result are discussed.

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