TY - JOUR
T1 - Monosynaptic excitation of dorsal medullary respiratory neurons by slowly adapting pulmonary stretch receptors
AU - Averill, D. B.
AU - Cameron, W. E.
AU - Berger, A. J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1984
Y1 - 1984
N2 - 1. The discharges of individual slowly adapting pulmonary stretch receptors (PSRs) and single respiratory neurons of the dorsal respiratory group (DRG) within the ventrolateral subnucleus of the solitary tract were recorded simultaneously in anesthetized, paralyzed, artificially ventilated cats. 2. DRG neurons were classified as P-cell, I-α, or I-β, based on the alteration in activity during respiratory cycles when lung inflation was withheld compared to activity when the lungs were inflated in phase with central inspiratory drive. In some cases, vagal stimulation was also used to classify respiratory neurons. 3. Synaptic input of PSRs onto DRG neurons was examined by the construction of cross-correlograms for the simultaneously recorded discharge of individual PSRs (reference events) and individual DRG neurons (correlated events). 4. Monosynaptic excitatory connections were demonstrated by peaks in 26% of the cross-correlograms of PSR and P-cell pairs and 20% of the cross-correlograms of PSR and I-β neuron pairs. The ratio of the peak number of occurrences to the background number of occurrences (k value) was comparable for P-cell and I-β neurons: 2.96 ± 2.09 and 1.62 ± 0.36 (mean ± SD), respectively, P-cells and I-β neurons also had similar short latencies for the peak of increased probability of discharge: 2.74 ± 0.53 and 2.57 ± 0.63 ms, respectively. 5. No evidence was obtained demonstrating synaptic connectivity between PSRs and I-α neurons. Interpretations of this negative result are discussed.
AB - 1. The discharges of individual slowly adapting pulmonary stretch receptors (PSRs) and single respiratory neurons of the dorsal respiratory group (DRG) within the ventrolateral subnucleus of the solitary tract were recorded simultaneously in anesthetized, paralyzed, artificially ventilated cats. 2. DRG neurons were classified as P-cell, I-α, or I-β, based on the alteration in activity during respiratory cycles when lung inflation was withheld compared to activity when the lungs were inflated in phase with central inspiratory drive. In some cases, vagal stimulation was also used to classify respiratory neurons. 3. Synaptic input of PSRs onto DRG neurons was examined by the construction of cross-correlograms for the simultaneously recorded discharge of individual PSRs (reference events) and individual DRG neurons (correlated events). 4. Monosynaptic excitatory connections were demonstrated by peaks in 26% of the cross-correlograms of PSR and P-cell pairs and 20% of the cross-correlograms of PSR and I-β neuron pairs. The ratio of the peak number of occurrences to the background number of occurrences (k value) was comparable for P-cell and I-β neurons: 2.96 ± 2.09 and 1.62 ± 0.36 (mean ± SD), respectively, P-cells and I-β neurons also had similar short latencies for the peak of increased probability of discharge: 2.74 ± 0.53 and 2.57 ± 0.63 ms, respectively. 5. No evidence was obtained demonstrating synaptic connectivity between PSRs and I-α neurons. Interpretations of this negative result are discussed.
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U2 - 10.1152/jn.1984.52.4.771
DO - 10.1152/jn.1984.52.4.771
M3 - Article
C2 - 6491716
AN - SCOPUS:0021188338
SN - 0022-3077
VL - 52
SP - 771
EP - 785
JO - Journal of neurophysiology
JF - Journal of neurophysiology
IS - 4
ER -