Monorhinal odor identification and depression scores in patients with seasonal affective disorder

Teodor T. Postolache, Richard L. Doty, Thomas A. Wehr, Lulu A. Jimma, Ling Han, Erick Turner, Jeffery R. Matthews, Alexander Neumeister, Charles No, Hans Kroger, Gerard E. Bruder, Norman E. Rosenthal

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Visual and olfactory pathways are interconnected. Olfactory deafferentation unmasks photoperiodic responsiveness in some nonphotoperiodic animals such as laboratory rats. By analogy, we hypothesized that olfactory deficits may unmask seasonal rhythms in certain individuals, namely those with seasonal affective disorder (SAD). Since previous studies suggest lateralized hemispheric dysfunction in SAD, and since olfactory neurons' primary projections are largely ipsilateral, we assessed olfactory identification performance on both the right and left side of the nose. Methods: Twenty-four patients with SAD and 24 matched controls were studied using a phenyl ethyl alcohol detection threshold test bilaterally and the University of Pennsylvania Smell Identification Test unilaterally. Subjects rated their mood using the Self Assessment Mood Scale for SAD. Patients' testing was done in both 'depressed' and 'improved on light' states. Results: No difference in olfactory performance was found between patients and controls or between patients before and after light treatment. However, right-side identification scores were negatively correlated with 'typical' depression scores (r=-0.56, P=0.006), while left-side olfactory scores were not. Atypical depression scores were unrelated to olfactory performance. Similar correlations emerged between the olfactory identification laterality quotient (Right-Left)/(Right+Left) and typical depressive scores (r=-0.64, P<0.001) and total depression scores (r=-0.59, P<0.004). Limitations: We studied a demographically heterogeneous sample and did not control for menstrual factors. Discussion: Our results add to previous evidence of lateralized hemispheric involvement in SAD and suggest that olfaction may be related to seasonal emotional rhythms in humans. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalJournal of Affective Disorders
Volume56
Issue number1
DOIs
StatePublished - Nov 1999
Externally publishedYes

Fingerprint

Seasonal Affective Disorder
Depression
Smell
Light
Olfactory Pathways
Visual Pathways
Nose
Ethanol
Odorants
Identification (Psychology)
Neurons

Keywords

  • Hemispheric laterality
  • Olfaction
  • Seasonal affective disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Monorhinal odor identification and depression scores in patients with seasonal affective disorder. / Postolache, Teodor T.; Doty, Richard L.; Wehr, Thomas A.; Jimma, Lulu A.; Han, Ling; Turner, Erick; Matthews, Jeffery R.; Neumeister, Alexander; No, Charles; Kroger, Hans; Bruder, Gerard E.; Rosenthal, Norman E.

In: Journal of Affective Disorders, Vol. 56, No. 1, 11.1999, p. 27-35.

Research output: Contribution to journalArticle

Postolache, TT, Doty, RL, Wehr, TA, Jimma, LA, Han, L, Turner, E, Matthews, JR, Neumeister, A, No, C, Kroger, H, Bruder, GE & Rosenthal, NE 1999, 'Monorhinal odor identification and depression scores in patients with seasonal affective disorder', Journal of Affective Disorders, vol. 56, no. 1, pp. 27-35. https://doi.org/10.1016/S0165-0327(99)00027-0
Postolache, Teodor T. ; Doty, Richard L. ; Wehr, Thomas A. ; Jimma, Lulu A. ; Han, Ling ; Turner, Erick ; Matthews, Jeffery R. ; Neumeister, Alexander ; No, Charles ; Kroger, Hans ; Bruder, Gerard E. ; Rosenthal, Norman E. / Monorhinal odor identification and depression scores in patients with seasonal affective disorder. In: Journal of Affective Disorders. 1999 ; Vol. 56, No. 1. pp. 27-35.
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AU - Doty, Richard L.

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AU - Han, Ling

AU - Turner, Erick

AU - Matthews, Jeffery R.

AU - Neumeister, Alexander

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AU - Kroger, Hans

AU - Bruder, Gerard E.

AU - Rosenthal, Norman E.

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N2 - Background: Visual and olfactory pathways are interconnected. Olfactory deafferentation unmasks photoperiodic responsiveness in some nonphotoperiodic animals such as laboratory rats. By analogy, we hypothesized that olfactory deficits may unmask seasonal rhythms in certain individuals, namely those with seasonal affective disorder (SAD). Since previous studies suggest lateralized hemispheric dysfunction in SAD, and since olfactory neurons' primary projections are largely ipsilateral, we assessed olfactory identification performance on both the right and left side of the nose. Methods: Twenty-four patients with SAD and 24 matched controls were studied using a phenyl ethyl alcohol detection threshold test bilaterally and the University of Pennsylvania Smell Identification Test unilaterally. Subjects rated their mood using the Self Assessment Mood Scale for SAD. Patients' testing was done in both 'depressed' and 'improved on light' states. Results: No difference in olfactory performance was found between patients and controls or between patients before and after light treatment. However, right-side identification scores were negatively correlated with 'typical' depression scores (r=-0.56, P=0.006), while left-side olfactory scores were not. Atypical depression scores were unrelated to olfactory performance. Similar correlations emerged between the olfactory identification laterality quotient (Right-Left)/(Right+Left) and typical depressive scores (r=-0.64, P<0.001) and total depression scores (r=-0.59, P<0.004). Limitations: We studied a demographically heterogeneous sample and did not control for menstrual factors. Discussion: Our results add to previous evidence of lateralized hemispheric involvement in SAD and suggest that olfaction may be related to seasonal emotional rhythms in humans. Copyright (C) 1999 Elsevier Science B.V.

AB - Background: Visual and olfactory pathways are interconnected. Olfactory deafferentation unmasks photoperiodic responsiveness in some nonphotoperiodic animals such as laboratory rats. By analogy, we hypothesized that olfactory deficits may unmask seasonal rhythms in certain individuals, namely those with seasonal affective disorder (SAD). Since previous studies suggest lateralized hemispheric dysfunction in SAD, and since olfactory neurons' primary projections are largely ipsilateral, we assessed olfactory identification performance on both the right and left side of the nose. Methods: Twenty-four patients with SAD and 24 matched controls were studied using a phenyl ethyl alcohol detection threshold test bilaterally and the University of Pennsylvania Smell Identification Test unilaterally. Subjects rated their mood using the Self Assessment Mood Scale for SAD. Patients' testing was done in both 'depressed' and 'improved on light' states. Results: No difference in olfactory performance was found between patients and controls or between patients before and after light treatment. However, right-side identification scores were negatively correlated with 'typical' depression scores (r=-0.56, P=0.006), while left-side olfactory scores were not. Atypical depression scores were unrelated to olfactory performance. Similar correlations emerged between the olfactory identification laterality quotient (Right-Left)/(Right+Left) and typical depressive scores (r=-0.64, P<0.001) and total depression scores (r=-0.59, P<0.004). Limitations: We studied a demographically heterogeneous sample and did not control for menstrual factors. Discussion: Our results add to previous evidence of lateralized hemispheric involvement in SAD and suggest that olfaction may be related to seasonal emotional rhythms in humans. Copyright (C) 1999 Elsevier Science B.V.

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