Monocyte DPP4 expression in human atherosclerosis is associated with obesity and dyslipidemia

Xiaoquan Rao; Jeffrey A. Deiuliis; Georgeta Mihai; Juliet Varghese; Chang Xia; Matthew B. Frieman; Carole Sztalryd; Xiao Jian Sun; Michael J. Quon; Simeon I. Taylor; Sanjay Ajagopalan; Jixin Zhong

doi:10.2337/dc17-0672

Monocyte DPP4 expression in human atherosclerosis is associated with obesity and dyslipidemia

Xiaoquan Rao, Jeffrey A. Deiuliis, Georgeta Mihai, Juliet Varghese, Chang Xia, Matthew B. Frieman, Carole Sztalryd, Xiao Jian Sun, Michael J. Quon, Simeon I. Taylor, Sanjay Ajagopalan, Jixin Zhong

Oregon Institute of Occupational Health Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Original language	English (US)
Pages (from-to)	e1-e3
Journal	Diabetes care
Volume	41
Issue number	1
DOIs	https://doi.org/10.2337/dc17-0672
State	Published - Jan 1 2018

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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10.2337/dc17-0672

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@article{6ccd5fcbcd8a4ad69a57238ee3afefd6,

title = "Monocyte DPP4 expression in human atherosclerosis is associated with obesity and dyslipidemia",

author = "Xiaoquan Rao and Deiuliis, {Jeffrey A.} and Georgeta Mihai and Juliet Varghese and Chang Xia and Frieman, {Matthew B.} and Carole Sztalryd and Sun, {Xiao Jian} and Quon, {Michael J.} and Taylor, {Simeon I.} and Sanjay Ajagopalan and Jixin Zhong",

note = "Funding Information: Acknowledgments. The authors thank clinical staff (Lisa Hafer at The Ohio State University, Kylene Broadwater and Steven Sawicki at the University of Maryland School of Medicine) for their help with subject recruitment and sample collection. Funding. This work was supported by grants from the National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases(K01DK105108),AmericanHeartAssociation (17GRNT33670485), American Association of Immunologists (CIIF-8745), and National Natural Science Foundation of China (81670431). X.R. was supported by grants from the National Institute of Environmental Health Sciences (K99ES026241) and the National Institute of Diabetes and Digestive and Kidney Diseases (T32DK098107). Duality of Interest. S.I.T. was previously employed by Bristol-Myers Squibb and currently owns stock in that company. S.R. has served as a consultant for Takeda Pharmaceuticals and Boehringer Ingelheim. J.Z. has received funding support from Boehringer Ingelheim (IIS2015-10485). No other potential conflicts of interest relevant to this article were reported. Author Contributions. X.R., C.X., and J.Z. researched data. G.M. and J.V. were responsible for MRI measurement of aortic plaque. X.R. and J.Z. wrote the manuscript. S.R. and J.Z. reviewed and edited the manuscript. J.A.D. and C.S. contributed to clinical tissue collection. M.B.F., X.J.S.,M.J.Q.,andS.I.T.contributedtodiscussion of experimental design. J.Z. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.",

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doi = "10.2337/dc17-0672",

language = "English (US)",

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T1 - Monocyte DPP4 expression in human atherosclerosis is associated with obesity and dyslipidemia

AU - Rao, Xiaoquan

AU - Deiuliis, Jeffrey A.

AU - Mihai, Georgeta

AU - Varghese, Juliet

AU - Xia, Chang

AU - Frieman, Matthew B.

AU - Sztalryd, Carole

AU - Sun, Xiao Jian

AU - Quon, Michael J.

AU - Taylor, Simeon I.

AU - Ajagopalan, Sanjay

AU - Zhong, Jixin

N1 - Funding Information: Acknowledgments. The authors thank clinical staff (Lisa Hafer at The Ohio State University, Kylene Broadwater and Steven Sawicki at the University of Maryland School of Medicine) for their help with subject recruitment and sample collection. Funding. This work was supported by grants from the National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases(K01DK105108),AmericanHeartAssociation (17GRNT33670485), American Association of Immunologists (CIIF-8745), and National Natural Science Foundation of China (81670431). X.R. was supported by grants from the National Institute of Environmental Health Sciences (K99ES026241) and the National Institute of Diabetes and Digestive and Kidney Diseases (T32DK098107). Duality of Interest. S.I.T. was previously employed by Bristol-Myers Squibb and currently owns stock in that company. S.R. has served as a consultant for Takeda Pharmaceuticals and Boehringer Ingelheim. J.Z. has received funding support from Boehringer Ingelheim (IIS2015-10485). No other potential conflicts of interest relevant to this article were reported. Author Contributions. X.R., C.X., and J.Z. researched data. G.M. and J.V. were responsible for MRI measurement of aortic plaque. X.R. and J.Z. wrote the manuscript. S.R. and J.Z. reviewed and edited the manuscript. J.A.D. and C.S. contributed to clinical tissue collection. M.B.F., X.J.S.,M.J.Q.,andS.I.T.contributedtodiscussion of experimental design. J.Z. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Monocyte DPP4 expression in human atherosclerosis is associated with obesity and dyslipidemia

ASJC Scopus subject areas

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