Monitoring the quality of life in patients with coronary artery disease

John A. Spertus, Jennifer A. Winder, Timothy A. Dewhurst, Richard (Rick) Deyo, Stephan D. Fihn

Research output: Contribution to journalArticle

304 Citations (Scopus)

Abstract

Monitoring the outcomes of treatment and quantifying patients' functional status have assumed a prominent role in both clinical trials and quality assurance programs. Because patients with coronary artery disease (CAD) may have comorbid illnesses, and because generic health status questionnaires may not focus on symptoms and impairments unique to coronary disease, a generic measure of health status may not be sufficient to detect important changes in patients' CAD. The responsiveness to clinical change of the Seattle Angina Questionnaire (SAQ), a disease-specific measure for CAD, was compared with that of the Short Form-36, a generic measure of health status. Both questionnaires were serially administered, 3 months apart, to 45 patients undergoing coronary angioplasty and to 130 patients with stable CAD. Most scales of both questionnaires improved significantly after coronary angioplasty. The responsiveness statistics of the SAQ exceeded those of the Short Form-36. Among 130 patients with initially stable angina, 33 deteriorated, 79 remained stable, and 18 improved over 3 months of observation. Mean SAQ scores changed significantly and appropriately in each of these groups. In contrast, none of the Short Form-36 scales detected these more subtle changes. Although useful in assessing overall function, a generic health status measure, such as the Short Form-36, may not be responsive enough to detect important clinical changes in patients' CAD. A disease-specific instrument, such as the SAQ, can be an important and relevant outcome measure in clinical trials or quality assurance programs.

Original languageEnglish (US)
Pages (from-to)1240-1244
Number of pages5
JournalThe American Journal of Cardiology
Volume74
Issue number12
DOIs
StatePublished - Dec 15 1994
Externally publishedYes

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Coronary Artery Disease
Quality of Life
Health Status
Angioplasty
Clinical Trials
Stable Angina
Surveys and Questionnaires
Coronary Disease
Observation
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Monitoring the quality of life in patients with coronary artery disease. / Spertus, John A.; Winder, Jennifer A.; Dewhurst, Timothy A.; Deyo, Richard (Rick); Fihn, Stephan D.

In: The American Journal of Cardiology, Vol. 74, No. 12, 15.12.1994, p. 1240-1244.

Research output: Contribution to journalArticle

Spertus, John A. ; Winder, Jennifer A. ; Dewhurst, Timothy A. ; Deyo, Richard (Rick) ; Fihn, Stephan D. / Monitoring the quality of life in patients with coronary artery disease. In: The American Journal of Cardiology. 1994 ; Vol. 74, No. 12. pp. 1240-1244.
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