Monitoring of tissue perfusion during esophagectomies with optical fiber probe spectroscopy

Dan Gareau, John Hunter, Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The specific optical spectra of tissues contain information about the biochemical composition. We present a simple optical fiber probe spectrometer design for noninvasive measurement of oxygen saturation in the microvasculature of stomach tissue. In a human Esophagectomy model with 23 patients, we measured the spectrum following surgical ligation of two of the three arterial paths to the stomach tissue that will become the anastamosis. Combining a diffusion model for semi-infinite slab remittance with absorption spectroscopy, we are able to specify the ratio of oxy-hemoglobin to deoxy-hemoglobin present in the tissue. We show a resting state of 0.47 (oxy-hemaglobin/total-hemaglobin) saturation decrease of 29% (p < 0.01) when arterial supply is reduced by artery ligation.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems VIII
DOIs
StatePublished - May 7 2010
EventAdvanced Biomedical and Clinical Diagnostic Systems VIII - San Francisco, CA, United States
Duration: Jan 24 2010Jan 26 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7555
ISSN (Print)1605-7422

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems VIII
CountryUnited States
CitySan Francisco, CA
Period1/24/101/26/10

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Monitoring of tissue perfusion during esophagectomies with optical fiber probe spectroscopy'. Together they form a unique fingerprint.

  • Cite this

    Gareau, D., Hunter, J., & Jacques, S. (2010). Monitoring of tissue perfusion during esophagectomies with optical fiber probe spectroscopy. In Advanced Biomedical and Clinical Diagnostic Systems VIII [75551C] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7555). https://doi.org/10.1117/12.843705