Moment analysis of multibreath nitrogen washout in young children

Michael Wall

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The purpose of this study was to determine whether online computerized moment analysis of multibreath N2 washout (MBNW) could be used as a method of estimating lung function in children too young to cooperate with routine pulmonary function testing. The limits of normal variability were determined from results obtained from duplicate studies performed on 36 healthy children ages 3-6 yr. Five healthy adults were studied for comparison. Test sensitivity was estimated by comparing the results in the healthy group to those of 10 age-matched children with cystic fibrosis (CF). Outcome variables of interest included functional residual capacity, the first-to-zeroth moment ratio (M1/M0), the second-to-zeroth moment ratio (M2/M0), and the lung clearance index. Test precision in the healthy group was high with the intrasubject coefficient of variation for all variables being 1/M0 and M2/M0 were both higher in CF than in the healthy group, 2.69 vs. 2.32 and 13.04 vs. 9.31, respectively (P

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalJournal of Applied Physiology
Volume59
Issue number1
StatePublished - 1985

Fingerprint

Nitrogen
Cystic Fibrosis
Lung
Functional Residual Capacity

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Moment analysis of multibreath nitrogen washout in young children. / Wall, Michael.

In: Journal of Applied Physiology, Vol. 59, No. 1, 1985, p. 274-279.

Research output: Contribution to journalArticle

@article{136b8e04b41f4055a9d3412338d1738e,
title = "Moment analysis of multibreath nitrogen washout in young children",
abstract = "The purpose of this study was to determine whether online computerized moment analysis of multibreath N2 washout (MBNW) could be used as a method of estimating lung function in children too young to cooperate with routine pulmonary function testing. The limits of normal variability were determined from results obtained from duplicate studies performed on 36 healthy children ages 3-6 yr. Five healthy adults were studied for comparison. Test sensitivity was estimated by comparing the results in the healthy group to those of 10 age-matched children with cystic fibrosis (CF). Outcome variables of interest included functional residual capacity, the first-to-zeroth moment ratio (M1/M0), the second-to-zeroth moment ratio (M2/M0), and the lung clearance index. Test precision in the healthy group was high with the intrasubject coefficient of variation for all variables being 1/M0 and M2/M0 were both higher in CF than in the healthy group, 2.69 vs. 2.32 and 13.04 vs. 9.31, respectively (P",
author = "Michael Wall",
year = "1985",
language = "English (US)",
volume = "59",
pages = "274--279",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Moment analysis of multibreath nitrogen washout in young children

AU - Wall, Michael

PY - 1985

Y1 - 1985

N2 - The purpose of this study was to determine whether online computerized moment analysis of multibreath N2 washout (MBNW) could be used as a method of estimating lung function in children too young to cooperate with routine pulmonary function testing. The limits of normal variability were determined from results obtained from duplicate studies performed on 36 healthy children ages 3-6 yr. Five healthy adults were studied for comparison. Test sensitivity was estimated by comparing the results in the healthy group to those of 10 age-matched children with cystic fibrosis (CF). Outcome variables of interest included functional residual capacity, the first-to-zeroth moment ratio (M1/M0), the second-to-zeroth moment ratio (M2/M0), and the lung clearance index. Test precision in the healthy group was high with the intrasubject coefficient of variation for all variables being 1/M0 and M2/M0 were both higher in CF than in the healthy group, 2.69 vs. 2.32 and 13.04 vs. 9.31, respectively (P

AB - The purpose of this study was to determine whether online computerized moment analysis of multibreath N2 washout (MBNW) could be used as a method of estimating lung function in children too young to cooperate with routine pulmonary function testing. The limits of normal variability were determined from results obtained from duplicate studies performed on 36 healthy children ages 3-6 yr. Five healthy adults were studied for comparison. Test sensitivity was estimated by comparing the results in the healthy group to those of 10 age-matched children with cystic fibrosis (CF). Outcome variables of interest included functional residual capacity, the first-to-zeroth moment ratio (M1/M0), the second-to-zeroth moment ratio (M2/M0), and the lung clearance index. Test precision in the healthy group was high with the intrasubject coefficient of variation for all variables being 1/M0 and M2/M0 were both higher in CF than in the healthy group, 2.69 vs. 2.32 and 13.04 vs. 9.31, respectively (P

UR - http://www.scopus.com/inward/record.url?scp=0021931814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021931814&partnerID=8YFLogxK

M3 - Article

C2 - 4030574

AN - SCOPUS:0021931814

VL - 59

SP - 274

EP - 279

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -