Abstract
Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.
Original language | English (US) |
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Pages (from-to) | 246-250 |
Number of pages | 5 |
Journal | Molecular Brain Research |
Volume | 87 |
Issue number | 2 |
DOIs | |
State | Published - Mar 5 2001 |
Keywords
- Aldehyde dehydrogenase
- Birdsong
- Retinoic acid
- Song control system
- Vocal learning
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience