Molecular targets of disulfiram action on song maturation in zebra finches

Natalia I. Denisenko-Nehrbass, Claudio V. Mello

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalMolecular Brain Research
Volume87
Issue number2
DOIs
StatePublished - Mar 5 2001

Keywords

  • Aldehyde dehydrogenase
  • Birdsong
  • Retinoic acid
  • Song control system
  • Vocal learning

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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