Molecular pathways

Tumor-derived microvesicles and their interactions with immune cells In vivo

Ferdinando Pucci, Mikael J. Pittet

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Cancer is not merely a cell-intrinsic genetic disease but also the result of complex cell-extrinsic interactions with host components, including immune cells. For example, effector T lymphocytes and natural killer cells are thought to participate in an immunosurveillance process, which eliminates neoplastic cells, whereas regulatory T lymphocytes and some myeloid cells, including macrophages, can create a milieu that prevents antitumor activity, supports tumor growth, and reduces survival of the host. Increasing evidence supports the notion that carcinoma cells communicate with immune cells directly, both within and away from the tumor stroma, and that this process fosters suppression of immunosurveillance and promotes tumor outgrowth. An important mode of communication between carcinoma cells and immune cells may involve tumor-derived microvesicles (tMV), also known as exosomes, ectosomes, or microparticles. These microvesicles carry lipids, proteins, mRNAs and microRNAs and travel short or long distances to deliver undegraded and undiluted material to other cells. Here, we consider the capacity of tMVs to control tumor-associated immune responses and highlight the known and unknown actions of tMVs in vivo. We also discuss why microvesicles may play a role in cancer diagnostics and prognostics and how they could be harnessed for anticancer therapy.

Original languageEnglish (US)
Pages (from-to)2598-2604
Number of pages7
JournalClinical Cancer Research
Volume19
Issue number10
DOIs
StatePublished - May 15 2013
Externally publishedYes

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Neoplasms
Immunologic Monitoring
Cell-Derived Microparticles
Exosomes
Carcinoma
Inborn Genetic Diseases
Regulatory T-Lymphocytes
Myeloid Cells
MicroRNAs
Cell Communication
Natural Killer Cells
Macrophages
T-Lymphocytes
Lipids
Messenger RNA
Growth
Proteins
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Molecular pathways : Tumor-derived microvesicles and their interactions with immune cells In vivo. / Pucci, Ferdinando; Pittet, Mikael J.

In: Clinical Cancer Research, Vol. 19, No. 10, 15.05.2013, p. 2598-2604.

Research output: Contribution to journalArticle

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