Molecular mechanisms of platelet-tumor cell adhesion under flow

Owen McCarty, Konstantinos Konstantopoulos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The ability of tumor cells to interact with platelets constitutes an indispensable determinant in the success of metastatic spread. This study was undertaken to investigate the sequence of molecular events mediating human colon (LS174T) carcinoma cell adhesion to surface adherent platelets under flow. A two-step process of tumor cell recruitment has been elucidated, involving LS174T tethering mediated primarily by platelet P-selectin, and subsequent arrest via platelet αΠbβ3. This cascade of events depicts an efficacious process for colon carcinoma arrest at sites of vascular injury.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages61
Number of pages1
Volume1
ISBN (Print)0780356756
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Cell adhesion
Platelets
Tumors
Cells
P-Selectin

ASJC Scopus subject areas

  • Bioengineering

Cite this

McCarty, O., & Konstantopoulos, K. (1999). Molecular mechanisms of platelet-tumor cell adhesion under flow. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 61). IEEE.

Molecular mechanisms of platelet-tumor cell adhesion under flow. / McCarty, Owen; Konstantopoulos, Konstantinos.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1999. p. 61.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

McCarty, O & Konstantopoulos, K 1999, Molecular mechanisms of platelet-tumor cell adhesion under flow. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, pp. 61, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.
McCarty O, Konstantopoulos K. Molecular mechanisms of platelet-tumor cell adhesion under flow. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. IEEE. 1999. p. 61
McCarty, Owen ; Konstantopoulos, Konstantinos. / Molecular mechanisms of platelet-tumor cell adhesion under flow. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1999. pp. 61
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