TY - GEN
T1 - Molecular mechanisms of platelet-tumor cell adhesion under flow
AU - McCarty, Owen
AU - Konstantopoulos, Konstantinos
PY - 1999
Y1 - 1999
N2 - The ability of tumor cells to interact with platelets constitutes an indispensable determinant in the success of metastatic spread. This study was undertaken to investigate the sequence of molecular events mediating human colon (LS174T) carcinoma cell adhesion to surface adherent platelets under flow. A two-step process of tumor cell recruitment has been elucidated, involving LS174T tethering mediated primarily by platelet P-selectin, and subsequent arrest via platelet αΠbβ3. This cascade of events depicts an efficacious process for colon carcinoma arrest at sites of vascular injury.
AB - The ability of tumor cells to interact with platelets constitutes an indispensable determinant in the success of metastatic spread. This study was undertaken to investigate the sequence of molecular events mediating human colon (LS174T) carcinoma cell adhesion to surface adherent platelets under flow. A two-step process of tumor cell recruitment has been elucidated, involving LS174T tethering mediated primarily by platelet P-selectin, and subsequent arrest via platelet αΠbβ3. This cascade of events depicts an efficacious process for colon carcinoma arrest at sites of vascular injury.
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M3 - Conference contribution
AN - SCOPUS:0033357143
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 61
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -