Molecular Mechanisms of Pathogenesis and Progression of Epithelial Ovarian Cancer

Robert C. Bast, Gordon Mills

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter describes the molecular mechanisms of disease progression of epithelial ovarian cancer. Ovarian cancer is neither a common nor a rare disease. Approximately 85% of ovarian cancers exhibit epithelial histology. Of the epithelial ovarian cancers, 90% are sporadic and occur in the absence of a strong family history. Some 10% of cases are hereditary, with ovarian or breast cancers in multiple generations of each kindred. Most hereditary cancers result from mutations of BRCA1 or BRCA2. Epidemiologic studies have generally failed to demonstrate chemical carcinogens that contribute to the development of sporadic ovarian cancer. One possible exception to this generalization is an association of ovarian cancer with the use of talc products, although the literature contains conflicting reports. Cigarette smoking has been associated with increased risk for a minority of ovarian cancers with mucinous histology. Several observations point to the importance of ovulation as a co-factor in the development of ovarian cancer. Factors that increase the number of ovulatory cycles also increase the risk of ovarian cancer, including early menarche, late menopause, and nulliparity. Conversely, factors that suppress ovulation-including multiple pregnancies and prolonged breastfeeding-decrease the risk of ovarian cancer.

Original languageEnglish (US)
Title of host publicationThe Ovary
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages625-645
Number of pages21
ISBN (Electronic)9780080542584
ISBN (Print)9780124445628
DOIs
StatePublished - Dec 18 2003
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Ovulation
Histology
Talc
Multiple Pregnancy
Menarche
Ovarian epithelial cancer
Menopause
Rare Diseases
Parity
Breast Feeding
Carcinogens
Disease Progression
Epidemiologic Studies
Smoking
Breast Neoplasms
Mutation
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Molecular Mechanisms of Pathogenesis and Progression of Epithelial Ovarian Cancer. / Bast, Robert C.; Mills, Gordon.

The Ovary: Second Edition. Elsevier Inc., 2003. p. 625-645.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bast, Robert C. ; Mills, Gordon. / Molecular Mechanisms of Pathogenesis and Progression of Epithelial Ovarian Cancer. The Ovary: Second Edition. Elsevier Inc., 2003. pp. 625-645
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