Molecular mechanisms of autism: a possible role for Ca2+ signaling

Jocelyn F. Krey, Ricardo E. Dolmetsch

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations

Abstract

Autism spectrum disorders (ASDs) are a group of developmental disorders characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. The molecular mechanisms that underlie ASDs are not known, but several recent developments suggest that some forms of autism are caused by failures in activity-dependent regulation of neural development. Mutations of several voltage-gated and ligand-gated ion channels that regulate neuronal excitability and Ca2+ signaling have been associated with ASDs. In addition, Ca2+-regulated signaling proteins involved in synapse formation and dendritic growth have been implicated in ASDs. These recent advances suggest a set of signaling pathways that might have a role in generating these increasingly prevalent disorders.

Original languageEnglish (US)
Pages (from-to)112-119
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume17
Issue number1
DOIs
StatePublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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