Molecular mechanisms and regulation of iron transport

Jayong Chung, Marianne Wessling-Resnick, Caroline Enns

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

Iron homeostasis is primarily maintained through regulation of its transport. This review summarizes recent discoveries in the field of iron transport that have shed light on the molecular mechanisms of dietary iron uptake, pathways for iron efflux to and between peripheral tissues, proteins implicated in organellar transport of iron (particularly the mitochondrion), and novel regulators that have been proposed to control iron assimilation. The transport of both transferrin-bound and nontransferrin-bound iron to peripheral tissues is discussed. Finally, the regulation of iron transport is also considered at the molecular level, with posttranscriptional, transcriptional, and posttranslational control mechanisms being reviewed.

Original languageEnglish (US)
Pages (from-to)151-182
Number of pages32
JournalCritical Reviews in Clinical Laboratory Sciences
Volume40
Issue number2
DOIs
StatePublished - Jan 1 2003

Keywords

  • ATP-binding cassette-7
  • Divalent metal transporter-1
  • Duodenal cytochrome b
  • Ferroportin-1
  • Frataxin
  • HFE
  • Hepcidin
  • Hephaestin
  • Iron transport
  • Mitochondrial iron transport
  • Nontransferrin-bound iron uptake
  • Transferrin
  • Transferrin receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Clinical Biochemistry
  • Biochemistry, medical

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