Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Motoyuki Hattori; Eric Gouaux

doi:10.1038/nature11010

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Motoyuki Hattori, Eric Gouaux

Vollum Institute

Research output: Contribution to journal › Article › peer-review

433 Scopus citations

Original language	English (US)
Pages (from-to)	207-212
Number of pages	6
Journal	Nature
Volume	485
Issue number	7397
DOIs	https://doi.org/10.1038/nature11010
State	Published - May 9 2012

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title = "Molecular mechanism of ATP binding and ion channel activation in P2X receptors",

author = "Motoyuki Hattori and Eric Gouaux",

note = "Funding Information: Acknowledgements We thank C. Alexander and D. C. Dawson for providing Xenopus oocytes, K. L. D{\"u}rr and T. Friedrich for providing the pCNA3.1x vector, L. Vaskalis for assistance with figure illustrations, K. J. Swartz and M. P. Kavanaugh for advice related to the oocyte experiments, and Gouaux laboratory members for discussions. We are also grateful to the staff at the Advanced Photon Source beamline 24-ID-C for help with X-ray data collection. This work was supported by a Japan Society for the Promotion of Science Postdoctoral Fellowship for Research Abroad (M.H.), by the American Asthma Foundation (E.G.) and the NIH (E.G.). E.G. is an investigator with the Howard Hughes Medical Institute.",

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N1 - Funding Information: Acknowledgements We thank C. Alexander and D. C. Dawson for providing Xenopus oocytes, K. L. Dürr and T. Friedrich for providing the pCNA3.1x vector, L. Vaskalis for assistance with figure illustrations, K. J. Swartz and M. P. Kavanaugh for advice related to the oocyte experiments, and Gouaux laboratory members for discussions. We are also grateful to the staff at the Advanced Photon Source beamline 24-ID-C for help with X-ray data collection. This work was supported by a Japan Society for the Promotion of Science Postdoctoral Fellowship for Research Abroad (M.H.), by the American Asthma Foundation (E.G.) and the NIH (E.G.). E.G. is an investigator with the Howard Hughes Medical Institute.

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Molecular mechanism of ATP binding and ion channel activation in P2X receptors

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