Molecular markers for colon diagnosis, prognosis and targeted therapy

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Colorectal adenocarcinoma (CRC), the second leading cancer-related death in the United States, remains a global public health issue. Sporadic CRC is considered the result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts in understanding the molecular pathways leading to CRC tumorigenesis may lead to identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well-published prognostic and predictive markers in CRC and examine their role in clinical practice.

Original languageEnglish (US)
Pages (from-to)96-102
Number of pages7
JournalJournal of surgical oncology
Volume111
Issue number1
DOIs
StatePublished - Jan 1 2015

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Keywords

  • BRAF V600E
  • KRAS
  • MSI
  • PI3K
  • TP53

ASJC Scopus subject areas

  • Surgery
  • Oncology

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