Molecular markers for colon diagnosis, prognosis and targeted therapy

Daniel O. Herzig; Vassiliki L. Tsikitis

doi:10.1002/jso.23806

Molecular markers for colon diagnosis, prognosis and targeted therapy

Daniel O. Herzig, Vassiliki L. Tsikitis

Surgery

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Colorectal adenocarcinoma (CRC), the second leading cancer-related death in the United States, remains a global public health issue. Sporadic CRC is considered the result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts in understanding the molecular pathways leading to CRC tumorigenesis may lead to identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well-published prognostic and predictive markers in CRC and examine their role in clinical practice.

Original language	English (US)
Pages (from-to)	96-102
Number of pages	7
Journal	Journal of surgical oncology
Volume	111
Issue number	1
DOIs	https://doi.org/10.1002/jso.23806
State	Published - Jan 1 2015

Keywords

BRAF V600E
KRAS
MSI
PI3K
TP53

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.23806

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title = "Molecular markers for colon diagnosis, prognosis and targeted therapy",

abstract = "Colorectal adenocarcinoma (CRC), the second leading cancer-related death in the United States, remains a global public health issue. Sporadic CRC is considered the result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts in understanding the molecular pathways leading to CRC tumorigenesis may lead to identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well-published prognostic and predictive markers in CRC and examine their role in clinical practice.",

keywords = "BRAF V600E, KRAS, MSI, PI3K, TP53",

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N2 - Colorectal adenocarcinoma (CRC), the second leading cancer-related death in the United States, remains a global public health issue. Sporadic CRC is considered the result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts in understanding the molecular pathways leading to CRC tumorigenesis may lead to identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well-published prognostic and predictive markers in CRC and examine their role in clinical practice.

AB - Colorectal adenocarcinoma (CRC), the second leading cancer-related death in the United States, remains a global public health issue. Sporadic CRC is considered the result of sequential mucosal changes from normal colonic mucosa to adenocarcinoma. Efforts in understanding the molecular pathways leading to CRC tumorigenesis may lead to identifying novel, individually tailored therapeutic targets for patients. In this review, we focus on well-published prognostic and predictive markers in CRC and examine their role in clinical practice.

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KW - KRAS

KW - MSI

KW - PI3K

KW - TP53

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Molecular markers for colon diagnosis, prognosis and targeted therapy

Abstract

Keywords

ASJC Scopus subject areas

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