Molecular imaging with targeted contrast ultrasound

Mark Piedra, Achim Allroggen, Jonathan R. Lindner

    Research output: Contribution to journalReview article

    22 Scopus citations

    Abstract

    Molecular imaging with contrast-enhanced ultrasound uses targeted microbubbles that are retained in diseased tissue. The resonant properties of these microbubbles produce acoustic signals in an ultrasound field. The microbubbles are targeted to diseased tissue by using certain chemical constituents in the microbubble shell or by attaching disease-specific ligands such as antibodies to the microbubble. In this review, we discuss the applications of this technique to pathological states in the cerebrovascular system including atherosclerosis, tumor angiogenesis, ischemia, intravascular thrombus, and inflammation.

    Original languageEnglish (US)
    Pages (from-to)66-74
    Number of pages9
    JournalCerebrovascular Diseases
    Volume27
    Issue numberSUPPL. 2
    DOIs
    StatePublished - Apr 1 2009

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    Keywords

    • Atherosclerosis
    • Contrast-enhanced ultrasound
    • Inflammation
    • Intravascular thrombus
    • Ischemia
    • Molecular imaging
    • Tumor angiogenesis

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Cardiology and Cardiovascular Medicine

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