Molecular imaging with targeted contrast ultrasound

Beat A. Kaufmann, Jonathan Lindner

    Research output: Contribution to journalArticle

    162 Citations (Scopus)

    Abstract

    Molecular imaging with contrast ultrasound relies on the detection of targeted microbubbles or other acoustically active nanoparticles. These microbubbles are retained in diseased tissue where they produce an acoustic signal because of their resonant properties in the ultrasound field. Targeting is accomplished either through manipulating the chemical properties of the microbubble shell or through conjugation of disease-specific ligands for the targeted molecule to the microbubble surface. As microbubbles cannot leave the intravascular space, the disease process must be characterized by molecular changes in the vascular compartment to be imaged. Inflammation, angiogenesis and thrombus formation are central pathophysiologic processes in many disease states and produce phenotypic changes in the vascular compartment. Thus, targeted contrast ultrasound in the future could aid in the diagnosis of such diverse diseases as atherosclerosis, transplant rejection and tumor-related angiogenesis.

    Original languageEnglish (US)
    Pages (from-to)11-16
    Number of pages6
    JournalCurrent Opinion in Biotechnology
    Volume18
    Issue number1
    DOIs
    StatePublished - Feb 2007

    Fingerprint

    Molecular imaging
    Microbubbles
    Molecular Imaging
    Ultrasonics
    Blood Vessels
    Transplants
    Chemical properties
    Graft Rejection
    Tumors
    Acoustics
    Nanoparticles
    Ligands
    Tissue
    Atherosclerosis
    Thrombosis
    Molecules
    Inflammation
    Neoplasms

    ASJC Scopus subject areas

    • Biotechnology
    • Biochemistry
    • Bioengineering

    Cite this

    Molecular imaging with targeted contrast ultrasound. / Kaufmann, Beat A.; Lindner, Jonathan.

    In: Current Opinion in Biotechnology, Vol. 18, No. 1, 02.2007, p. 11-16.

    Research output: Contribution to journalArticle

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