TY - JOUR
T1 - Molecular imaging with contrast enhanced ultrasound
AU - Chadderdon, Scott M.
AU - Kaul, Sanjiv
N1 - Funding Information:
From the Cardiovascular Division, Oregon Health and Science Uni-versity, Portland, OR. Scott M. Chadderdon: Supported in part by Fellow-to-Faculty Award (0875005 N), American Heart Association, Dallas, TX. Reprint requests: Sanjiv Kaul, MD, Cardiovascular Division, UHN 62, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239; kauls@ohsu.edu. J Nucl Cardiol 2010;17:667–77. 1071-3581/$34.00 Copyright © 2010 by the American Society of Nuclear Cardiology. doi:10.1007/s12350-010-9240-4
PY - 2010/8
Y1 - 2010/8
N2 - Noninvasive cardiovascular imaging techniques are well-established for studying cardiovascular anatomy and physiology. Over the past decade contrast enhanced imaging techniques have been developed that are also able to characterize the molecular constituents of cardiovascular disease. In this regard, microbubble-and ultrasound-based techniques have the ability to assess a broad range of molecular components of cardiovascular pathology such as inflammation, recent ischemia, atherosclerosis, acute transplant rejection, angiogenesis, and thrombosis. The advantages of ultrasound-and microbubble-based approach include the ability to assess multiple molecular disease markers without exposure to ionizing radiation or prolonged imaging protocols. This review highlights the development of microbubble-based molecular imaging, describes successful experimental conditions in which they have been studied, and postulates the importance of translating this technique into the clinical practice.
AB - Noninvasive cardiovascular imaging techniques are well-established for studying cardiovascular anatomy and physiology. Over the past decade contrast enhanced imaging techniques have been developed that are also able to characterize the molecular constituents of cardiovascular disease. In this regard, microbubble-and ultrasound-based techniques have the ability to assess a broad range of molecular components of cardiovascular pathology such as inflammation, recent ischemia, atherosclerosis, acute transplant rejection, angiogenesis, and thrombosis. The advantages of ultrasound-and microbubble-based approach include the ability to assess multiple molecular disease markers without exposure to ionizing radiation or prolonged imaging protocols. This review highlights the development of microbubble-based molecular imaging, describes successful experimental conditions in which they have been studied, and postulates the importance of translating this technique into the clinical practice.
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U2 - 10.1007/s12350-010-9240-4
DO - 10.1007/s12350-010-9240-4
M3 - Review article
C2 - 20467852
AN - SCOPUS:79953155328
SN - 1071-3581
VL - 17
SP - 667
EP - 677
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 4
ER -