Molecular Imaging of Myocardial and Vascular Disorders With Ultrasound

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    Methods for noninvasive imaging of specific disease-related molecular changes are being developed in order to expand and improve diagnostic capabilities and to enhance therapeutic decision making in the clinical setting. These new techniques have also started to be incorporated into research programs in order to better characterize pathophysiology or evaluate treatment efficacy. Molecular imaging with contrast-enhanced ultrasound relies on the detection of the acoustic signal produced by either microbubbles or other acoustically active particulate agents that are targeted to sites of disease. This review describes the progress that has been made in the development and testing of methods for contrast ultrasound molecular imaging of cardiovascular disease. Specifically, topics that will be addressed include: 1) the bioengineering and detection schemes for targeted probes; 2) specific disease processes (myocardial ischemia, atherosclerosis, and transplant rejection) where molecular imaging may play a role; and 3) the potential role of ultrasound as a molecular imaging technique.

    Original languageEnglish (US)
    Pages (from-to)204-211
    Number of pages8
    JournalJACC: Cardiovascular Imaging
    Volume3
    Issue number2
    DOIs
    StatePublished - Feb 2010

    Fingerprint

    Molecular Imaging
    Blood Vessels
    Microbubbles
    Bioengineering
    Graft Rejection
    Acoustics
    Myocardial Ischemia
    Ultrasonography
    Atherosclerosis
    Cardiovascular Diseases
    Research
    Therapeutics

    Keywords

    • contrast ultrasound
    • microbubbles
    • molecular imaging

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Radiology Nuclear Medicine and imaging

    Cite this

    Molecular Imaging of Myocardial and Vascular Disorders With Ultrasound. / Lindner, Jonathan.

    In: JACC: Cardiovascular Imaging, Vol. 3, No. 2, 02.2010, p. 204-211.

    Research output: Contribution to journalArticle

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