Molecular imaging of cardiac amyloidosis

Ahmad Masri; Syed Bukhari; Yvonne S. Eisele; Prem Soman

doi:10.2967/jnumed.120.245381

Molecular imaging of cardiac amyloidosis

Ahmad Masri, Syed Bukhari, Yvonne S. Eisele, Prem Soman

Knight Cardiovascular Institute

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Transthyretin and light-chain amyloidosis are the 2 main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering the first effective treatment options for this condition.

Original language	English (US)
Pages (from-to)	965-970
Number of pages	6
Journal	Journal of Nuclear Medicine
Volume	61
Issue number	7
DOIs	https://doi.org/10.2967/jnumed.120.245381
State	Published - Jul 1 2020

Keywords

ATTR
Bone-seeking tracers
Cardiac amyloidosis
Molecular imaging
SPECT

ASJC Scopus subject areas

General Medicine

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title = "Molecular imaging of cardiac amyloidosis",

abstract = "Transthyretin and light-chain amyloidosis are the 2 main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering the first effective treatment options for this condition.",

keywords = "ATTR, Bone-seeking tracers, Cardiac amyloidosis, Molecular imaging, SPECT",

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AU - Bukhari, Syed

AU - Eisele, Yvonne S.

AU - Soman, Prem

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Y1 - 2020/7/1

N2 - Transthyretin and light-chain amyloidosis are the 2 main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering the first effective treatment options for this condition.

AB - Transthyretin and light-chain amyloidosis are the 2 main causes of cardiac amyloidosis. Recent developments in molecular imaging have transformed our ability to diagnose transthyretin cardiac amyloidosis noninvasively and unmasked a hitherto unrecognized prevalence of the disease. This review summarizes the current and evolving imaging approaches, their molecular structural basis, and the gaps in imaging capabilities that have arisen as a result of parallel developments in pharmacotherapy delivering the first effective treatment options for this condition.

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KW - Molecular imaging

KW - SPECT

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Molecular imaging of cardiac amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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