Molecular genetic and proteomic analysis of synchronous malignant gliomas

Z. Zhuang; Y. S. Lee; W. Zeng; M. Furuta; T. Valyi-Nagy; M. D. Johnson; C. L. Vnencak-Jones; R. L. Woltjer; R. J. Weil

doi:10.1212/WNL.62.12.2316

Molecular genetic and proteomic analysis of synchronous malignant gliomas

Z. Zhuang, Y. S. Lee, W. Zeng, M. Furuta, T. Valyi-Nagy, M. D. Johnson, C. L. Vnencak-Jones, R. L. Woltjer, R. J. Weil

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Described is a patient with concurrent discrete gliomas: a pleomorphic xanthoastrocytoma with anaplastic features and an anaplastic oligoastrocytoma. The distinct and morphologically dissimilar tumors demonstrated similar genetic abnormalities by loss of heterozygosity and comparative genome hybridization. Clonality and proteomic analyses highlighted an independent origin for the two tumors. Proteomic methods may prove useful in cases where the differential diagnosis and pathogenetic origin of tumors are uncertain, as well as more globally for its ability to provide insight into specific expression of proteins that may serve as unique markers of tumorigenesis or as novel targets of therapy.

Original language	English (US)
Pages (from-to)	2316-2319
Number of pages	4
Journal	Neurology
Volume	62
Issue number	12
DOIs	https://doi.org/10.1212/WNL.62.12.2316
State	Published - Jun 22 2004
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/WNL.62.12.2316

Cite this

@article{f95ecb92581e43eaa6af1a618d37076e,

title = "Molecular genetic and proteomic analysis of synchronous malignant gliomas",

abstract = "Described is a patient with concurrent discrete gliomas: a pleomorphic xanthoastrocytoma with anaplastic features and an anaplastic oligoastrocytoma. The distinct and morphologically dissimilar tumors demonstrated similar genetic abnormalities by loss of heterozygosity and comparative genome hybridization. Clonality and proteomic analyses highlighted an independent origin for the two tumors. Proteomic methods may prove useful in cases where the differential diagnosis and pathogenetic origin of tumors are uncertain, as well as more globally for its ability to provide insight into specific expression of proteins that may serve as unique markers of tumorigenesis or as novel targets of therapy.",

author = "Z. Zhuang and Lee, {Y. S.} and W. Zeng and M. Furuta and T. Valyi-Nagy and Johnson, {M. D.} and Vnencak-Jones, {C. L.} and Woltjer, {R. L.} and Weil, {R. J.}",

year = "2004",

month = jun,

day = "22",

doi = "10.1212/WNL.62.12.2316",

language = "English (US)",

volume = "62",

pages = "2316--2319",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Molecular genetic and proteomic analysis of synchronous malignant gliomas

AU - Zhuang, Z.

AU - Lee, Y. S.

AU - Zeng, W.

AU - Furuta, M.

AU - Valyi-Nagy, T.

AU - Johnson, M. D.

AU - Vnencak-Jones, C. L.

AU - Woltjer, R. L.

AU - Weil, R. J.

PY - 2004/6/22

Y1 - 2004/6/22

N2 - Described is a patient with concurrent discrete gliomas: a pleomorphic xanthoastrocytoma with anaplastic features and an anaplastic oligoastrocytoma. The distinct and morphologically dissimilar tumors demonstrated similar genetic abnormalities by loss of heterozygosity and comparative genome hybridization. Clonality and proteomic analyses highlighted an independent origin for the two tumors. Proteomic methods may prove useful in cases where the differential diagnosis and pathogenetic origin of tumors are uncertain, as well as more globally for its ability to provide insight into specific expression of proteins that may serve as unique markers of tumorigenesis or as novel targets of therapy.

AB - Described is a patient with concurrent discrete gliomas: a pleomorphic xanthoastrocytoma with anaplastic features and an anaplastic oligoastrocytoma. The distinct and morphologically dissimilar tumors demonstrated similar genetic abnormalities by loss of heterozygosity and comparative genome hybridization. Clonality and proteomic analyses highlighted an independent origin for the two tumors. Proteomic methods may prove useful in cases where the differential diagnosis and pathogenetic origin of tumors are uncertain, as well as more globally for its ability to provide insight into specific expression of proteins that may serve as unique markers of tumorigenesis or as novel targets of therapy.

UR - http://www.scopus.com/inward/record.url?scp=2942726331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942726331&partnerID=8YFLogxK

U2 - 10.1212/WNL.62.12.2316

DO - 10.1212/WNL.62.12.2316

M3 - Article

C2 - 15210906

AN - SCOPUS:2942726331

SN - 0028-3878

VL - 62

SP - 2316

EP - 2319

JO - Neurology

JF - Neurology

IS - 12

ER -

Molecular genetic and proteomic analysis of synchronous malignant gliomas

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this