Abstract
Recent studies implicate the inhibitory neurotransmitter γ- aminobutyric acid (GABA) in many neurochemical actions of ethanol and a variety of behavioral responses to acute and chronic ethanol treatment. However, the molecular mechanisms responsible for genetic differences in initial neurochemical or behavioral sensitivity to ethanol, and adaptation following chronic or repeated ethanol administration, remain to be elucidated. Pharmacogenetic research will increasingly move toward mapping, cloning, identification, and functional analysis of the genes underlying the actions of ethanol. The approaches discussed here permit molecular analysis of both known and previously unknown genes regulating behavioral sensitivity to ethanol. The synthesis of molecular methods and behavioral genetics offers immediate hope for delineating the role of the GABA(A) receptor complex, and other determinants of GABAergic neurotransmission, in determining genetic variation in behavioral responses to ethanol.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-323 |
| Number of pages | 11 |
| Journal | Behavior genetics |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 1996 |
Keywords
- Ethanol
- GABA(A) receptor subunit
- genetic mapping
- glutamic acid decarboxylase
- quantitative trait loci
- γ-aminobutyric acid
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Genetics
- Genetics(clinical)