Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol

Kari Johnson Buck

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Recent studies implicate the inhibitory neurotransmitter γ- aminobutyric acid (GABA) in many neurochemical actions of ethanol and a variety of behavioral responses to acute and chronic ethanol treatment. However, the molecular mechanisms responsible for genetic differences in initial neurochemical or behavioral sensitivity to ethanol, and adaptation following chronic or repeated ethanol administration, remain to be elucidated. Pharmacogenetic research will increasingly move toward mapping, cloning, identification, and functional analysis of the genes underlying the actions of ethanol. The approaches discussed here permit molecular analysis of both known and previously unknown genes regulating behavioral sensitivity to ethanol. The synthesis of molecular methods and behavioral genetics offers immediate hope for delineating the role of the GABA(A) receptor complex, and other determinants of GABAergic neurotransmission, in determining genetic variation in behavioral responses to ethanol.

Original languageEnglish (US)
Pages (from-to)313-323
Number of pages11
JournalBehavior genetics
Issue number3
StatePublished - May 1996
Externally publishedYes


  • Ethanol
  • GABA(A) receptor subunit
  • genetic mapping
  • glutamic acid decarboxylase
  • quantitative trait loci
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)


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