Molecular genetic analysis of a small bowel primitive neuroectodermal tumor

Douglas K. Graham, Linda C. Stork, Qi Wei, J. David Ingram, Frederick M. Karrer, Gary W. Mierau, Mark A. Lovell

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We present a pediatric peripheral primitive neuroectodermal tumor (pPNET) localized exclusively to the small bowel. The tumor presented in an adolescent male and the diagnosis was confirmed by electron microscopy, CD99 immunopositivity, and molecular genetic analysis that demonstrated an EWS-FLI1 type 2 fusion transcript. This case report and a review of the literature underscore the considerable phenotypic overlap in EWS-related tumors in this site and the necessity for molecular genetic analysis to permit accurate classification.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalPediatric and Developmental Pathology
Volume5
Issue number1
DOIs
StatePublished - Apr 16 2002

Keywords

  • EWS-FLI1
  • Ewing's sarcoma
  • Pediatric oncology
  • Peripheral primitive neuroectodermal tumor
  • Small bowel tumor
  • pPNET

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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