TY - JOUR
T1 - Molecular epidemiology of envelope glycoprotein H of human cytomegalovirus
AU - Chou, Sunwen
N1 - Funding Information:
Received 3 February 1992; revised 22 April 1992. Financial support: Department of Veterans Affairs research funds. Ten complete gH coding sequences have been submitted to Genbank, and the accession and strain numbers. respectively. are as follows: M94228. C074; M94229. C076; M94230. C079; M94231. C325; M94232. C327; M94233. C336; M94234. C338; M94235. C351; M94236. C352; M94237. C353. Reprints or correspondence: Dr. Sunwen Chou. Infectious Disease Section II IF. VA Medical Center. P.O. Box 1034. Portland OR 97207.
PY - 1992/9
Y1 - 1992/9
N2 - The complete envelope glycoprotein H (gH) coding sequences of 10 clinical strains of cytomegalovirus (CMV) were determined and compared with those of laboratory strains AD169 and Towne. Their translated peptide sequences segregated into two groups, exemplified by AD 169 and Towne. Peptide variation was mostly group-specific and was clustered in the first 37 amino acids, including the signal sequence; in the rest of the molecule, there were scattered amino acid substitutions, usually in single residues. Compared with CMV envelope glycoprotein B, gH is more highly conserved among strains and may be expected to have limited immunologic diversity.
AB - The complete envelope glycoprotein H (gH) coding sequences of 10 clinical strains of cytomegalovirus (CMV) were determined and compared with those of laboratory strains AD169 and Towne. Their translated peptide sequences segregated into two groups, exemplified by AD 169 and Towne. Peptide variation was mostly group-specific and was clustered in the first 37 amino acids, including the signal sequence; in the rest of the molecule, there were scattered amino acid substitutions, usually in single residues. Compared with CMV envelope glycoprotein B, gH is more highly conserved among strains and may be expected to have limited immunologic diversity.
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U2 - 10.1093/infdis/166.3.604
DO - 10.1093/infdis/166.3.604
M3 - Article
C2 - 1323623
AN - SCOPUS:0026669792
SN - 0022-1899
VL - 166
SP - 604
EP - 607
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -