Molecular diagnosis and ocular imaging of varicella zoster virus associated neuroretinitis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To report a case of varicella zoster virus associated neuroretinitis confirmed via polymerase chain reaction analysis of ocular fluid. Observations: A 30-year-old man presented with a 1-week history of decreased vision in his left eye and ulcerative skin lesions above his left eyebrow. On exam, he had clinical findings consistent with neuroretinitis characterized by optic disc edema and formation of a macular star. Polymerase chain reaction analysis of aqueous fluid was positive for varicella zoster virus. He was treated with oral valacyclovir with excellent resolution of his symptoms and clinical findings. Conclusions and importance: Varicella zoster virus is a rare cause of neuroretinitis. We report for the first time a case of varicella zoster virus associated neuroretinitis confirmed by polymerase chain reaction analysis of ocular fluid. Molecular testing of ocular tissue may lead to a definitive diagnosis.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalAmerican Journal of Ophthalmology Case Reports
Volume11
DOIs
StatePublished - Sep 1 2018

Fingerprint

Retinitis
Human Herpesvirus 3
valacyclovir
Polymerase Chain Reaction
Eyebrows
Papilledema
Skin

Keywords

  • Neuroretinitis
  • Uveitis
  • Varicella zoster virus

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{d332c84f7d3b401599a1a11f25b978ee,
title = "Molecular diagnosis and ocular imaging of varicella zoster virus associated neuroretinitis",
abstract = "Purpose: To report a case of varicella zoster virus associated neuroretinitis confirmed via polymerase chain reaction analysis of ocular fluid. Observations: A 30-year-old man presented with a 1-week history of decreased vision in his left eye and ulcerative skin lesions above his left eyebrow. On exam, he had clinical findings consistent with neuroretinitis characterized by optic disc edema and formation of a macular star. Polymerase chain reaction analysis of aqueous fluid was positive for varicella zoster virus. He was treated with oral valacyclovir with excellent resolution of his symptoms and clinical findings. Conclusions and importance: Varicella zoster virus is a rare cause of neuroretinitis. We report for the first time a case of varicella zoster virus associated neuroretinitis confirmed by polymerase chain reaction analysis of ocular fluid. Molecular testing of ocular tissue may lead to a definitive diagnosis.",
keywords = "Neuroretinitis, Uveitis, Varicella zoster virus",
author = "Choi, {Rene Y.} and Lauer, {Andreas (Andy)} and Rosenbaum, {James (Jim)}",
year = "2018",
month = "9",
day = "1",
doi = "10.1016/j.ajoc.2018.07.002",
language = "English (US)",
volume = "11",
pages = "146--148",
journal = "American Journal of Ophthalmology Case Reports",
issn = "2451-9936",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Molecular diagnosis and ocular imaging of varicella zoster virus associated neuroretinitis

AU - Choi, Rene Y.

AU - Lauer, Andreas (Andy)

AU - Rosenbaum, James (Jim)

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose: To report a case of varicella zoster virus associated neuroretinitis confirmed via polymerase chain reaction analysis of ocular fluid. Observations: A 30-year-old man presented with a 1-week history of decreased vision in his left eye and ulcerative skin lesions above his left eyebrow. On exam, he had clinical findings consistent with neuroretinitis characterized by optic disc edema and formation of a macular star. Polymerase chain reaction analysis of aqueous fluid was positive for varicella zoster virus. He was treated with oral valacyclovir with excellent resolution of his symptoms and clinical findings. Conclusions and importance: Varicella zoster virus is a rare cause of neuroretinitis. We report for the first time a case of varicella zoster virus associated neuroretinitis confirmed by polymerase chain reaction analysis of ocular fluid. Molecular testing of ocular tissue may lead to a definitive diagnosis.

AB - Purpose: To report a case of varicella zoster virus associated neuroretinitis confirmed via polymerase chain reaction analysis of ocular fluid. Observations: A 30-year-old man presented with a 1-week history of decreased vision in his left eye and ulcerative skin lesions above his left eyebrow. On exam, he had clinical findings consistent with neuroretinitis characterized by optic disc edema and formation of a macular star. Polymerase chain reaction analysis of aqueous fluid was positive for varicella zoster virus. He was treated with oral valacyclovir with excellent resolution of his symptoms and clinical findings. Conclusions and importance: Varicella zoster virus is a rare cause of neuroretinitis. We report for the first time a case of varicella zoster virus associated neuroretinitis confirmed by polymerase chain reaction analysis of ocular fluid. Molecular testing of ocular tissue may lead to a definitive diagnosis.

KW - Neuroretinitis

KW - Uveitis

KW - Varicella zoster virus

UR - http://www.scopus.com/inward/record.url?scp=85050121959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050121959&partnerID=8YFLogxK

U2 - 10.1016/j.ajoc.2018.07.002

DO - 10.1016/j.ajoc.2018.07.002

M3 - Article

AN - SCOPUS:85050121959

VL - 11

SP - 146

EP - 148

JO - American Journal of Ophthalmology Case Reports

JF - American Journal of Ophthalmology Case Reports

SN - 2451-9936

ER -