Molecular determinants in targeted therapy for esophageal adenocarcinoma

Daniel Vallböhmer, Jeffrey H. Peters, Hidekazu Kuramochi, Daniel Oh, Dong Yang, Daisuke Shimizu, Steven R. DeMeester, Jeffrey A. Hagen, Parakrama T. Chandrasoma, Kathleen D. Danenberg, Peter V. Danenberg, Tom R. DeMeester, John Vetto, Fiemu Nwariaku, Fabrizio Michelassi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Hypothesis: Cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) are useful biological determinants in targeted therapy for esophageal adenocarcinoma. Design: Prospective analysis. Setting: University tertiary referral center. Patients: Sixteen patients with squamous mucosa and normal results of a pH study without mucosal injury (control group), 15 with Barrett esophagus (metaplasia group), and 44 with adenocarcinoma (carcinoma group). Interventions: Biopsy specimens were obtained 3 cm above the gastroesophageal junction. Dysplastic tissue was additionally isolated from 9 of the patients in the carcinoma group. After laser-capture microdissection, quantitative real-time polymerase chain reaction was used to measure gene expression across the spectrum of the metaplasia-dysplasia-carcinoma sequence. Main Outcome Measures: Expression of COX-2, VEGF, and EGFR in each patient group. Results: Expression of both COX-2 and VEGF was significantly up-regulated in patients with metaplasia, dysplasia, and cancer compared with controls (P

Original languageEnglish (US)
Pages (from-to)476-482
Number of pages7
JournalArchives of Surgery
Volume141
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

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Adenocarcinoma
Cyclooxygenase 2
Vascular Endothelial Growth Factor A
Barrett Esophagus
Metaplasia
Carcinoma
Epidermal Growth Factor Receptor
Laser Capture Microdissection
Therapeutics
Esophagogastric Junction
Tertiary Care Centers
Real-Time Polymerase Chain Reaction
Mucous Membrane
Outcome Assessment (Health Care)
Biopsy
Gene Expression
Control Groups
Wounds and Injuries
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Vallböhmer, D., Peters, J. H., Kuramochi, H., Oh, D., Yang, D., Shimizu, D., ... Michelassi, F. (2006). Molecular determinants in targeted therapy for esophageal adenocarcinoma. Archives of Surgery, 141(5), 476-482. https://doi.org/10.1001/archsurg.141.5.476

Molecular determinants in targeted therapy for esophageal adenocarcinoma. / Vallböhmer, Daniel; Peters, Jeffrey H.; Kuramochi, Hidekazu; Oh, Daniel; Yang, Dong; Shimizu, Daisuke; DeMeester, Steven R.; Hagen, Jeffrey A.; Chandrasoma, Parakrama T.; Danenberg, Kathleen D.; Danenberg, Peter V.; DeMeester, Tom R.; Vetto, John; Nwariaku, Fiemu; Michelassi, Fabrizio.

In: Archives of Surgery, Vol. 141, No. 5, 05.2006, p. 476-482.

Research output: Contribution to journalArticle

Vallböhmer, D, Peters, JH, Kuramochi, H, Oh, D, Yang, D, Shimizu, D, DeMeester, SR, Hagen, JA, Chandrasoma, PT, Danenberg, KD, Danenberg, PV, DeMeester, TR, Vetto, J, Nwariaku, F & Michelassi, F 2006, 'Molecular determinants in targeted therapy for esophageal adenocarcinoma', Archives of Surgery, vol. 141, no. 5, pp. 476-482. https://doi.org/10.1001/archsurg.141.5.476
Vallböhmer D, Peters JH, Kuramochi H, Oh D, Yang D, Shimizu D et al. Molecular determinants in targeted therapy for esophageal adenocarcinoma. Archives of Surgery. 2006 May;141(5):476-482. https://doi.org/10.1001/archsurg.141.5.476
Vallböhmer, Daniel ; Peters, Jeffrey H. ; Kuramochi, Hidekazu ; Oh, Daniel ; Yang, Dong ; Shimizu, Daisuke ; DeMeester, Steven R. ; Hagen, Jeffrey A. ; Chandrasoma, Parakrama T. ; Danenberg, Kathleen D. ; Danenberg, Peter V. ; DeMeester, Tom R. ; Vetto, John ; Nwariaku, Fiemu ; Michelassi, Fabrizio. / Molecular determinants in targeted therapy for esophageal adenocarcinoma. In: Archives of Surgery. 2006 ; Vol. 141, No. 5. pp. 476-482.
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