Molecular cytogenetics: Solid tumors and leukemia

Joe Gray, M. G. Pallavicini

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Acute leukemia represents one of the best-studied malignancies. Consequently, numerous dogmas have evolved over the years. One dogma to which we subscribe is that leukemia is a genetic disease and that the behavior of leukemic cells and their response to therapy is determined largely by their genetic characteristics. The relative ease of metaphase generation and culture of single leukemic cells, well-defined morphologic criteria, and availability of phenotyping reagents has contributed to a wealth of information about the karyotypic, genetic, and functional properties of these cells. Nevertheless, establishment of genotype-phenotype relationships has been particularly elusive. The genetic evolution of leukemias and the consequences of specific aberrations remains to be determined. We describe the power of new molecular cytogenetic tools, fluorescence in situ hybridization, and comparative genomic hybridization to measure the genetic evolution of leukemic cells. Lessons learned from application of these techniques to solid tumors and speculations about similar approaches to analysis of leukemia are addressed.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalBlood Cells
Volume19
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Cytogenetics
Leukemia
Molecular Evolution
Neoplasms
Inborn Genetic Diseases
Comparative Genomic Hybridization
Metaphase
Fluorescence In Situ Hybridization
Genotype
Phenotype
Therapeutics

Keywords

  • leukemia
  • molecular cytogenetics
  • solid tumors

ASJC Scopus subject areas

  • Hematology

Cite this

Gray, J., & Pallavicini, M. G. (1993). Molecular cytogenetics: Solid tumors and leukemia. Blood Cells, 19(3), 677-683.

Molecular cytogenetics : Solid tumors and leukemia. / Gray, Joe; Pallavicini, M. G.

In: Blood Cells, Vol. 19, No. 3, 1993, p. 677-683.

Research output: Contribution to journalArticle

Gray, J & Pallavicini, MG 1993, 'Molecular cytogenetics: Solid tumors and leukemia', Blood Cells, vol. 19, no. 3, pp. 677-683.
Gray, Joe ; Pallavicini, M. G. / Molecular cytogenetics : Solid tumors and leukemia. In: Blood Cells. 1993 ; Vol. 19, No. 3. pp. 677-683.
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