Molecular cytogenetics of human breast cancer

J. W. Gray; C. Collins; I. C. Henderson; J. Isola; A. Kallioniemi; O. P. Kallioniemi; H. Nakamura; D. Pinkel; T. Stokke; M. Tanner; F. Waldman

doi:10.1101/SQB.1994.059.01.074

Molecular cytogenetics of human breast cancer

J. W. Gray, C. Collins, I. C. Henderson, J. Isola, A. Kallioniemi, O. P. Kallioniemi, H. Nakamura, D. Pinkel, T. Stokke, M. Tanner, F. Waldman

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Our studies of human breast cancer using CGH and FISH with precisely mapped probes have revealed a surprising amount of intratumor and intertumor heterogeneity in human breast cancers. However, some regions of abnormal copy number are found frequently. We believe that the regions of frequent abnormality harbor novel cancer genes, and that identification of these is important for diagnosis, prognostication, and the development of new therapies.

Original language	English (US)
Pages (from-to)	645-652
Number of pages	8
Journal	Cold Spring Harbor symposia on quantitative biology
Volume	59
DOIs	https://doi.org/10.1101/SQB.1994.059.01.074
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.1101/SQB.1994.059.01.074

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author = "Gray, {J. W.} and C. Collins and Henderson, {I. C.} and J. Isola and A. Kallioniemi and Kallioniemi, {O. P.} and H. Nakamura and D. Pinkel and T. Stokke and M. Tanner and F. Waldman",

year = "1994",

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T1 - Molecular cytogenetics of human breast cancer

AU - Gray, J. W.

AU - Collins, C.

AU - Henderson, I. C.

AU - Isola, J.

AU - Kallioniemi, A.

AU - Kallioniemi, O. P.

AU - Nakamura, H.

AU - Pinkel, D.

AU - Stokke, T.

AU - Tanner, M.

AU - Waldman, F.

PY - 1994

Y1 - 1994

N2 - Our studies of human breast cancer using CGH and FISH with precisely mapped probes have revealed a surprising amount of intratumor and intertumor heterogeneity in human breast cancers. However, some regions of abnormal copy number are found frequently. We believe that the regions of frequent abnormality harbor novel cancer genes, and that identification of these is important for diagnosis, prognostication, and the development of new therapies.

AB - Our studies of human breast cancer using CGH and FISH with precisely mapped probes have revealed a surprising amount of intratumor and intertumor heterogeneity in human breast cancers. However, some regions of abnormal copy number are found frequently. We believe that the regions of frequent abnormality harbor novel cancer genes, and that identification of these is important for diagnosis, prognostication, and the development of new therapies.

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JO - Cold Spring Harbor Symposia on Quantitative Biology

JF - Cold Spring Harbor Symposia on Quantitative Biology

ER -

Molecular cytogenetics of human breast cancer

Abstract

ASJC Scopus subject areas

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