Molecular cytogenetics of human breast cancer

J. W. Gray, C. Collins, I. C. Henderson, J. Isola, A. Kallioniemi, O. P. Kallioniemi, H. Nakamura, D. Pinkel, T. Stokke, M. Tanner, F. Waldman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Our studies of human breast cancer using CGH and FISH with precisely mapped probes have revealed a surprising amount of intratumor and intertumor heterogeneity in human breast cancers. However, some regions of abnormal copy number are found frequently. We believe that the regions of frequent abnormality harbor novel cancer genes, and that identification of these is important for diagnosis, prognostication, and the development of new therapies.

Original languageEnglish (US)
Pages (from-to)645-652
Number of pages8
JournalCold Spring Harbor symposia on quantitative biology
Volume59
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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    Gray, J. W., Collins, C., Henderson, I. C., Isola, J., Kallioniemi, A., Kallioniemi, O. P., Nakamura, H., Pinkel, D., Stokke, T., Tanner, M., & Waldman, F. (1994). Molecular cytogenetics of human breast cancer. Cold Spring Harbor symposia on quantitative biology, 59, 645-652. https://doi.org/10.1101/SQB.1994.059.01.074