Molecular cytogenetics in human cancer diagnosis

Joe Gray, D. Pinkel

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

This report summarizes the application of fluorescence in situ hybridization for detection and diagnosis of human cancers and for detection of residual cancer cells. This approach allows individual interphase cancer cells to be stained so that aberrations such as aneusomies, translocations, deletions, and gene amplification can be seen in the light microscope. This is accomplished using probes for repeated sequences found at the chromosome centromeres, whole chromosome probes, and/or probes for specific aberrant sequences.

Original languageEnglish (US)
Pages (from-to)1536-1542
Number of pages7
JournalCancer
Volume69
Issue number6 SUPPL.
StatePublished - 1992
Externally publishedYes

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Cytogenetics
Chromosomes
Centromere
Gene Amplification
Interphase
Residual Neoplasm
Fluorescence In Situ Hybridization
Neoplasms
Light

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gray, J., & Pinkel, D. (1992). Molecular cytogenetics in human cancer diagnosis. Cancer, 69(6 SUPPL.), 1536-1542.

Molecular cytogenetics in human cancer diagnosis. / Gray, Joe; Pinkel, D.

In: Cancer, Vol. 69, No. 6 SUPPL., 1992, p. 1536-1542.

Research output: Contribution to journalArticle

Gray, J & Pinkel, D 1992, 'Molecular cytogenetics in human cancer diagnosis', Cancer, vol. 69, no. 6 SUPPL., pp. 1536-1542.
Gray J, Pinkel D. Molecular cytogenetics in human cancer diagnosis. Cancer. 1992;69(6 SUPPL.):1536-1542.
Gray, Joe ; Pinkel, D. / Molecular cytogenetics in human cancer diagnosis. In: Cancer. 1992 ; Vol. 69, No. 6 SUPPL. pp. 1536-1542.
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