Molecular cytogenetics in human cancer diagnosis

Joe W. Gray, Daniel Pinkel

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

This report summarizes the application of fluorescence in situ hybridization for detection and diagnosis of human cancers and for detection of residual cancer cells. This approach allows individual interphase cancer cells to be stained so that aberrations such as aneusomies, translocations, deletions, and gene amplification can be seen in the light microscope. This is accomplished using probes for repeated sequences found at the chromosome centromeres, whole chromosome probes, and/or probes for specific aberrant sequences. Cancer 1992; 69:1536‐1542.

Original languageEnglish (US)
Pages (from-to)1536-1542
Number of pages7
JournalCancer
Volume69
Issue number6 S
DOIs
StatePublished - Mar 15 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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