Molecular cytogenetics: Diagnosis and prognostic assessment

Joe W. Gray; Anne Kallioniemi; Olli Kallioniemi; Maria Pallavicini; Fred Waldman; Daniel Pinkel

doi:10.1016/0958-1669(92)90006-5

Molecular cytogenetics: Diagnosis and prognostic assessment

Joe W. Gray, Anne Kallioniemi, Olli Kallioniemi, Maria Pallavicini, Fred Waldman, Daniel Pinkel

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.

Original language	English (US)
Pages (from-to)	623-631
Number of pages	9
Journal	Current Opinion in Biotechnology
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/0958-1669(92)90006-5
State	Published - Dec 1992
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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title = "Molecular cytogenetics: Diagnosis and prognostic assessment",

abstract = "This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.",

author = "Gray, {Joe W.} and Anne Kallioniemi and Olli Kallioniemi and Maria Pallavicini and Fred Waldman and Daniel Pinkel",

note = "Funding Information: I would like to thank W-L Kuo, K Matsumura, M Sakamoto and H-U Weier for their assistance in the preparation of this manuscript. This work was supported by US PHS grants CA45919, HD17665, CA44768 and Imagenetics.",

year = "1992",

month = dec,

doi = "10.1016/0958-1669(92)90006-5",

language = "English (US)",

volume = "3",

pages = "623--631",

journal = "Current Opinion in Biotechnology",

issn = "0958-1669",

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TY - JOUR

T1 - Molecular cytogenetics

T2 - Diagnosis and prognostic assessment

AU - Gray, Joe W.

AU - Kallioniemi, Anne

AU - Kallioniemi, Olli

AU - Pallavicini, Maria

AU - Waldman, Fred

AU - Pinkel, Daniel

N1 - Funding Information: I would like to thank W-L Kuo, K Matsumura, M Sakamoto and H-U Weier for their assistance in the preparation of this manuscript. This work was supported by US PHS grants CA45919, HD17665, CA44768 and Imagenetics.

PY - 1992/12

Y1 - 1992/12

N2 - This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.

AB - This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.

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DO - 10.1016/0958-1669(92)90006-5

M3 - Article

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VL - 3

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EP - 631

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

IS - 6

ER -

Molecular cytogenetics: Diagnosis and prognostic assessment

Abstract

ASJC Scopus subject areas

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