TY - JOUR
T1 - Molecular cytogenetics
T2 - Diagnosis and prognostic assessment
AU - Gray, Joe W.
AU - Kallioniemi, Anne
AU - Kallioniemi, Olli
AU - Pallavicini, Maria
AU - Waldman, Fred
AU - Pinkel, Daniel
PY - 1992/12
Y1 - 1992/12
N2 - This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.
AB - This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.
UR - http://www.scopus.com/inward/record.url?scp=0027024541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027024541&partnerID=8YFLogxK
U2 - 10.1016/0958-1669(92)90006-5
DO - 10.1016/0958-1669(92)90006-5
M3 - Article
C2 - 1369118
AN - SCOPUS:0027024541
VL - 3
SP - 623
EP - 631
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
SN - 0958-1669
IS - 6
ER -