Molecular cytogenetics: Diagnosis and prognostic assessment

Joe W. Gray, Anne Kallioniemi, Olli Kallioniemi, Maria Pallavicini, Fred Waldman, Daniel Pinkel

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


This review describes molecular cytogenetic techniques for detection and characterization of genetic aberrations associated with human disease. The techniques of fluorescence in situ hybridization, primed in situ labeling and comparative genome hybridization are described, as are probes for repeated sequences, whole chromosomes and specific loci. Also reviewed are applications of these technologies to pre-and neonatal diagnosis and to the characterization of human malignancies.

Original languageEnglish (US)
Pages (from-to)623-631
Number of pages9
JournalCurrent Opinion in Biotechnology
Issue number6
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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