Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene

Dafe A. Uwanogho, Zoë Hardcastle, Piroska Balogh, Ghazala Mirza, Kent L. Thornburg, Jiannis Ragoussis, Raul T. Sharpe

    Research output: Contribution to journalArticle

    29 Scopus citations

    Abstract

    Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of phosphotyrosine. PTPs are known to be involved in many signal transduction pathways leading to cell growth, differentiation, and oncogenic transformation. We have cloned a new family of novel protein tyrosine phosphatase-like genes, the Ptpl (protein tyrosine phosphatase-like; proline instead of catalytic arginine) gene family. This gene family is composed of at least three members, and we describe here the developmental expression pattern and chromosomal location for one of these genes, Ptpla. In situ hybridization studies revealed that Ptpla expression was first detected at embryonic day 8.5 in muscle progenitors and later in differentiated muscle types: in the developing heart, throughout the liver and lungs, and in a number of neural crest derivatives including the dorsal root and trigeminal ganglia. Postnatally Ptpla was expressed in a number of adult tissues including cardiac and skeletal muscle, liver, testis, and kidney. The early expression pattern of this gene and its persistent expression in adult tissues suggest that it may have an important role in the development, differentiation, and maintenance of a number of different tissue types. The human homologue of Ptpla (PTPLA) was cloned and shown to map to 10p13-p14. (C) 1999 Academic Press.

    Original languageEnglish (US)
    Pages (from-to)406-416
    Number of pages11
    JournalGenomics
    Volume62
    Issue number3
    DOIs
    StatePublished - Dec 15 1999

    ASJC Scopus subject areas

    • Genetics

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