Molecular biology of the dopamine receptors

Olivier Civelli, James R. Bunzow, David K. Grandy, Qun Yong Zhou, Hubert H.M. Van Tol

    Research output: Contribution to journalArticle

    212 Scopus citations

    Abstract

    Because of their importance in pathophysiology, the dopamine receptors have been the subjects of intense pharmacological and physiological research. Their structures have remained mostly unknown until recently with the application of molecular biological approaches. The cloning of the first dopamine receptor, the D2 receptor opened a new era in dopamine receptor research. It has led not only to new studies of its own biology but also to the characterization of the other dopamine receptors. The most striking conclusion of this fast moving research is that the dopamine receptors are more diverse than expected from their pharmacological characterizations. We discuss here the history of the cloning of the dopamine receptors and the impact that this research had on our understanding of the dopamine system.

    Original languageEnglish (US)
    Pages (from-to)277-286
    Number of pages10
    JournalEuropean Journal of Pharmacology: Molecular Pharmacology
    Volume207
    Issue number4
    DOIs
    StatePublished - Aug 14 1991

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    Keywords

    • (Novel receptors)
    • Cloning
    • Dopamine D receptor
    • Dopamine D receptor
    • Dopamine D receptor
    • Dopamine D receptor
    • Dopamine receptors
    • Molecular biology

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Civelli, O., Bunzow, J. R., Grandy, D. K., Zhou, Q. Y., & Van Tol, H. H. M. (1991). Molecular biology of the dopamine receptors. European Journal of Pharmacology: Molecular Pharmacology, 207(4), 277-286. https://doi.org/10.1016/0922-4106(91)90001-X