Molecular basis of mechanosensory transduction

Peter Barr-Gillespie, R. G. Walker

Research output: Contribution to journalArticle

468 Citations (Scopus)

Abstract

Mechanotransduction - a cell's conversion of a mechanical stimulus into an electrical signal - reveals vital features of an organism's environment. From hair cells and skin mechanoreceptors in vertebrates, to bristle receptors in flies and touch receptors in worms, mechanically sensitive cells are essential in the life of an organism. The scarcity of these cells and the uniqueness of their transduction mechanisms have conspired to slow molecular characterization of the ensembles that carry out mechanotransduction. But recent progress in both invertebrates and vertebrates is beginning to reveal the identities of proteins essential for transduction.

Original languageEnglish (US)
Pages (from-to)194-202
Number of pages9
JournalNature
Volume413
Issue number6852
DOIs
StatePublished - Sep 13 2001

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Cellular Mechanotransduction
Vertebrates
Mechanoreceptors
Touch
Invertebrates
Diptera
Skin
Proteins

ASJC Scopus subject areas

  • General

Cite this

Molecular basis of mechanosensory transduction. / Barr-Gillespie, Peter; Walker, R. G.

In: Nature, Vol. 413, No. 6852, 13.09.2001, p. 194-202.

Research output: Contribution to journalArticle

Barr-Gillespie, Peter ; Walker, R. G. / Molecular basis of mechanosensory transduction. In: Nature. 2001 ; Vol. 413, No. 6852. pp. 194-202.
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