Molecular and functional aspects of menstruation in the macaque

Robert M. Brenner, Ov Slayden

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    Much of our understanding of the molecular control of menstruation arises from laboratory models that experimentally recapitulate some, but not all, aspects of uterine bleeding observed in women. These models include: in vitro culture of endometrial explants or isolated endometrial cells, transplantation of human endometrial tissue into immunodeficient mice and the induction of endometrial breakdown in appropriately pretreated mice. Each of these models has contributed to our understanding of molecular and cellular mechanisms of menstruation, but nonhuman primates, especially macaques, are the animal model of choice for evaluating therapies for menstrual disorders. In this chapter we review some basic aspects of menstruation, with special emphasis on the macaque model and its relevance to the clinical issues of irregular and heavy menstrual bleeding (HMB).

    Original languageEnglish (US)
    Pages (from-to)309-318
    Number of pages10
    JournalReviews in Endocrine and Metabolic Disorders
    Volume13
    Issue number4
    DOIs
    Publication statusPublished - Dec 2012

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    Keywords

    • Cervix
    • Endometrium
    • Heavy menstrual bleeding
    • Hormonal control
    • Macaque
    • Menstrual blood loss
    • Menstruation
    • Model

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

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