Molecular and functional aspects of menstruation in the macaque

Robert M. Brenner, Ov Slayden

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Much of our understanding of the molecular control of menstruation arises from laboratory models that experimentally recapitulate some, but not all, aspects of uterine bleeding observed in women. These models include: in vitro culture of endometrial explants or isolated endometrial cells, transplantation of human endometrial tissue into immunodeficient mice and the induction of endometrial breakdown in appropriately pretreated mice. Each of these models has contributed to our understanding of molecular and cellular mechanisms of menstruation, but nonhuman primates, especially macaques, are the animal model of choice for evaluating therapies for menstrual disorders. In this chapter we review some basic aspects of menstruation, with special emphasis on the macaque model and its relevance to the clinical issues of irregular and heavy menstrual bleeding (HMB).

    Original languageEnglish (US)
    Pages (from-to)309-318
    Number of pages10
    JournalReviews in Endocrine and Metabolic Disorders
    Volume13
    Issue number4
    DOIs
    StatePublished - Dec 2012

    Fingerprint

    Menstruation
    Macaca
    Uterine Hemorrhage
    Cell Transplantation
    Primates
    Animal Models
    Hemorrhage
    Therapeutics

    Keywords

    • Cervix
    • Endometrium
    • Heavy menstrual bleeding
    • Hormonal control
    • Macaque
    • Menstrual blood loss
    • Menstruation
    • Model

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Molecular and functional aspects of menstruation in the macaque. / Brenner, Robert M.; Slayden, Ov.

    In: Reviews in Endocrine and Metabolic Disorders, Vol. 13, No. 4, 12.2012, p. 309-318.

    Research output: Contribution to journalArticle

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