TY - JOUR
T1 - Chapter 12
T2 - Molecular and cellular studies on brain calcium/calmodulin-dependent protein kinase II
AU - Soderling, T. R.
AU - Fukunaga, K.
AU - Brickey, D. A.
AU - Fong, Y. L.
AU - Rich, D. P.
AU - Smith, K.
AU - Colbran, R. J.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - This chapter discusses brain CaM-kinase II with a particular focus on its unique regulatory properties, its regulation in cultured brain cells, and its physiological functions. CaM-kinase II has widespread tissue distribution as oligomeric isozyme forms and is particularly abundant in the brain. In certain regions of the brain, such as hippocampus, it constitutes up to 2% of total protein, which probably makes it the most abundant enzyme in these tissues. CaM-kinase II is localized presynaptically where it is involved in Ca2+-dependent regulation of neurotransmitter biosynthesis and exocytosis. At excitatory synapses in forebrain, there is a thickening of the postsynaptic membrane called the postsynaptic density (PSD), and CaM-kinase II constitutes about 30–50% of the protein in the PSD. These excitatory synapses are subject to a usage-dependent enhancement of synaptic transmission called long-term potentiation (LTP)—a popular model for learning and memory.
AB - This chapter discusses brain CaM-kinase II with a particular focus on its unique regulatory properties, its regulation in cultured brain cells, and its physiological functions. CaM-kinase II has widespread tissue distribution as oligomeric isozyme forms and is particularly abundant in the brain. In certain regions of the brain, such as hippocampus, it constitutes up to 2% of total protein, which probably makes it the most abundant enzyme in these tissues. CaM-kinase II is localized presynaptically where it is involved in Ca2+-dependent regulation of neurotransmitter biosynthesis and exocytosis. At excitatory synapses in forebrain, there is a thickening of the postsynaptic membrane called the postsynaptic density (PSD), and CaM-kinase II constitutes about 30–50% of the protein in the PSD. These excitatory synapses are subject to a usage-dependent enhancement of synaptic transmission called long-term potentiation (LTP)—a popular model for learning and memory.
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U2 - 10.1016/S0079-6123(08)61722-7
DO - 10.1016/S0079-6123(08)61722-7
M3 - Article
C2 - 1796140
AN - SCOPUS:0026338060
SN - 0079-6123
VL - 89
SP - 169
EP - 183
JO - Progress in Brain Research
JF - Progress in Brain Research
IS - C
ER -