Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects

S. James Ratnakar, Mark Woods, Angelo J M Lubag, Zoltán Kovács, A. Dean Sherry

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The chemical exchange saturation transfer (CEST) efficiency for a series Eu3+-based tetraamide complexes bearing p-substituents on a single coordinating pendant arm is highly sensitive to water exchange rates. The CEST effect increases in the order Me <MeO <F CO2tBu <CN H. These results show that CEST contrast can be modulated by changes in electron density at a single ligating atom, and this forms the basis of creating imaging agents that respond to chemical oxidation and reduction.

Original languageEnglish (US)
Pages (from-to)6-7
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number1
DOIs
StatePublished - Jan 9 2008
Externally publishedYes

Fingerprint

Europium
Oxidation-Reduction
Modulation
Electrons
Water
Bearings (structural)
Carrier concentration
Imaging techniques
Atoms
Oxidation

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects. / Ratnakar, S. James; Woods, Mark; Lubag, Angelo J M; Kovács, Zoltán; Sherry, A. Dean.

In: Journal of the American Chemical Society, Vol. 130, No. 1, 09.01.2008, p. 6-7.

Research output: Contribution to journalArticle

Ratnakar, S. James ; Woods, Mark ; Lubag, Angelo J M ; Kovács, Zoltán ; Sherry, A. Dean. / Modulation of water exchange in europium(III) DOTA-tetraamide complexes via electronic substituent effects. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 1. pp. 6-7.
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