Modulation of the coagulation cascade using recombinant factor VIIa and activated protein C in a severely injured trauma patient

Adnan Z. Rizvi, Denetta S. Slone, Martin Schreiber

    Research output: Contribution to journalArticle


    Exsanguination after trauma remains a leading cause of early death in severely injured patients [1]. Sepsis and multiple organ failure are significant causes of mortality in severely injured trauma patients who survive their injury and require a prolonged ICU hospitalization [2]. Despite advances in operative technique and critical care medicine, the treatment options for patients with coagulopathic hemorrhage or severe sepsis have remained relatively unchanged. We report a unique case in which pharmacological modulators of coagulation, recombinant Factor VIIa, and activated protein C were successfully used to treat massive hemorr-hage and then severe sepsis in a severely injured trauma patient.

    Original languageEnglish (US)
    Pages (from-to)399-403
    Number of pages5
    JournalEuropean Journal of Trauma
    Issue number4
    Publication statusPublished - Aug 2006



    • Activated protein C
    • Hemorrhage
    • Recombinant factor VIIa
    • Sepsis
    • Trauma

    ASJC Scopus subject areas

    • Surgery

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