Modulation of progestin secretion in ovarian cells by 17β-hydroxy-5α-androstan-3-one (dihydrotestosterone): A direct demonstration in monolayer culture

David W. Schomberg, R. L. Stouffer, L. Tyrey

    Research output: Contribution to journalArticle

    72 Scopus citations

    Abstract

    These studies with a monolayer system of porcine granulosa cells provide a direct demonstration of the ability of androgen to stimulate progestin secretion by ovarian cells. A preferential action of the more potent androgens, dihydrotestosterone and testosterone, was shown but only dihydrotestosterone demonstrated the capacity to stimulate progestin secretion throughout the culture period. Estradiol 17-β markedly depressed progestin synthesis. The results suggest a modulatory role for androgens in the development of full steroidogenic potential by ovarian granulosa cells during follicular development.

    Original languageEnglish (US)
    Pages (from-to)77-81
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume68
    Issue number1
    DOIs
    StatePublished - Jan 12 1976

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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