Modulation of DNA synthesis by muscarinic cholinergic receptors

L. G. Costa, Marina Guizzetti, J. Oberdoerster, K. Yagle, P. Costa-Mallen, B. Tita, F. Bordi, A. Vitalone, M. Palmery, P. Valeri

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Acetylcholine muscarinic receptors are a family of five G-protein-coupled receptors widely distributed in the central nervous system and in peripheral organs. Activation of certain subtypes of muscarinic receptors (M1, M3, M5) has been found to modulate DNA synthesis in a number of cell types. In several cell types acetylcholine, by activating endogenous or transfected muscarinic receptors, can indeed elicit cell proliferation. In other cell types, however, or under different experimental conditions, activation of muscarinic receptors has no effect, or inhibits DNA synthesis. A large number of intracellular pathways are being investigated to define the mechanisms involved in these effects of muscarinic receptors; these include among others, phospholipase D, protein kinases C and mitogen-activated-protein kinases. The ability of acetylcholine to modulate DNA synthesis through muscarinic receptors may be relevant in the context of brain development and neoplastic growth.

Original languageEnglish (US)
Pages (from-to)227-236
Number of pages10
JournalGrowth Factors
Volume18
Issue number4
StatePublished - 2001
Externally publishedYes

Fingerprint

Cholinergic Receptors
Muscarinic Receptors
Cholinergic Agents
Modulation
DNA
Acetylcholine
Chemical activation
Muscarinic M3 Receptors
Muscarinic M1 Receptors
Phospholipase D
Cell proliferation
Neurology
G-Protein-Coupled Receptors
Mitogen-Activated Protein Kinases
Growth and Development
Protein Kinase C
Brain
Central Nervous System
Cell Count
Cell Proliferation

Keywords

  • DNA synthesis
  • Modulation
  • Receptors

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology

Cite this

Costa, L. G., Guizzetti, M., Oberdoerster, J., Yagle, K., Costa-Mallen, P., Tita, B., ... Valeri, P. (2001). Modulation of DNA synthesis by muscarinic cholinergic receptors. Growth Factors, 18(4), 227-236.

Modulation of DNA synthesis by muscarinic cholinergic receptors. / Costa, L. G.; Guizzetti, Marina; Oberdoerster, J.; Yagle, K.; Costa-Mallen, P.; Tita, B.; Bordi, F.; Vitalone, A.; Palmery, M.; Valeri, P.

In: Growth Factors, Vol. 18, No. 4, 2001, p. 227-236.

Research output: Contribution to journalArticle

Costa, LG, Guizzetti, M, Oberdoerster, J, Yagle, K, Costa-Mallen, P, Tita, B, Bordi, F, Vitalone, A, Palmery, M & Valeri, P 2001, 'Modulation of DNA synthesis by muscarinic cholinergic receptors', Growth Factors, vol. 18, no. 4, pp. 227-236.
Costa LG, Guizzetti M, Oberdoerster J, Yagle K, Costa-Mallen P, Tita B et al. Modulation of DNA synthesis by muscarinic cholinergic receptors. Growth Factors. 2001;18(4):227-236.
Costa, L. G. ; Guizzetti, Marina ; Oberdoerster, J. ; Yagle, K. ; Costa-Mallen, P. ; Tita, B. ; Bordi, F. ; Vitalone, A. ; Palmery, M. ; Valeri, P. / Modulation of DNA synthesis by muscarinic cholinergic receptors. In: Growth Factors. 2001 ; Vol. 18, No. 4. pp. 227-236.
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