Modulation of Bcl-2 expression: A potential component of estrogen protection in NT2 neurons

Cherie A. Singer, Keith L. Rogers, Daniel M. Dorsa

Research output: Contribution to journalArticle

172 Scopus citations

Abstract

Neuroprotective effects of estrogen have been demonstrated against a variety of cytotoxic insults. We present data here addressing a possible mechanism of estrogen neuroprotection in the human teratocarcinoma cell line NT2 terminally differentiated to a neuronal phenotype. Cell death induced by H2O2 or glutamate results in a dose-dependent cell death of NT2 neurons, while 24 h of estrogen pretreatment significantly enhances neuronal viability. Bcl-2 expression has been shown to reduce oxidative stress and prevent cell death. In NT2 neurons, Bcl-2 levels are dramatically elevated upon differentiation and are further enhanced with estrogen treatment. These results suggest that neuroprotective effects of estrogen may be related to increases in Bcl-2 expression.

Original languageEnglish (US)
Pages (from-to)2565-2568
Number of pages4
JournalNeuroReport
Volume9
Issue number11
DOIs
StatePublished - Aug 3 1998

Keywords

  • Bcl-2
  • Estrogen
  • Glutamate
  • Neuroprotection
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

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