Modified phenazines from an indonesian streptomyces sp

Serge Fotso, Dwi Andreas Santosa, Rasti Saraswati, Jongtae Yang, Taifo Mahmud, T. Mark Zabriskie, Philip J. Proteau

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalJournal of Natural Products
Volume73
Issue number3
DOIs
StatePublished - Mar 26 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Fotso, S., Santosa, D. A., Saraswati, R., Yang, J., Mahmud, T., Mark Zabriskie, T., & Proteau, P. J. (2010). Modified phenazines from an indonesian streptomyces sp. Journal of Natural Products, 73(3), 472-475. https://doi.org/10.1021/np9005647