Modified phenazines from an indonesian streptomyces sp

Serge Fotso, Dwi Andreas Santosa, Rasti Saraswati, Jongtae Yang, Taifo Mahmud, T. Mark Zabriskie, Philip J. Proteau

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalJournal of Natural Products
Issue number3
StatePublished - Mar 26 2010
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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