Modified phenazines from an indonesian streptomyces sp

Serge Fotso, Dwi Andreas Santosa, Rasti Saraswati, Jongtae Yang, Taifo Mahmud, Mark Zabriskie, Philip J. Proteau

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fractionation of the extract from the Indonesian Streptomyces sp. ICBB8198 as directed by the antibacterial activity delivered the known phenazine antibiotics griseoluteic acid (1a) and griseolutein A (1b), as well as two new phenazine derivatives (2 and 3). In addition, the known compounds spirodionic acid, dihydrosarkomycins, and 6-ethyl-4-hydroxy-3,5-dimethyl-2H-pyran-2-one (4a), along with the new pyrone 3,6-diethyl-4-hydroxy-5-methyl-2H-pyran-2-one (4b), were isolated. We report here the isolation, structure elucidation, and antibiotic activity of the new metabolites as well as a hypothetical pathway for the formation of the new phenazine derivatives.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalJournal of Natural Products
Volume73
Issue number3
DOIs
StatePublished - Mar 26 2010
Externally publishedYes

Fingerprint

Phenazines
Streptomyces
Pyrans
Pyrones
Anti-Bacterial Agents
Derivatives
Fractionation
Metabolites
Acids
phenazine

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Fotso, S., Santosa, D. A., Saraswati, R., Yang, J., Mahmud, T., Zabriskie, M., & Proteau, P. J. (2010). Modified phenazines from an indonesian streptomyces sp. Journal of Natural Products, 73(3), 472-475. https://doi.org/10.1021/np9005647

Modified phenazines from an indonesian streptomyces sp. / Fotso, Serge; Santosa, Dwi Andreas; Saraswati, Rasti; Yang, Jongtae; Mahmud, Taifo; Zabriskie, Mark; Proteau, Philip J.

In: Journal of Natural Products, Vol. 73, No. 3, 26.03.2010, p. 472-475.

Research output: Contribution to journalArticle

Fotso, S, Santosa, DA, Saraswati, R, Yang, J, Mahmud, T, Zabriskie, M & Proteau, PJ 2010, 'Modified phenazines from an indonesian streptomyces sp', Journal of Natural Products, vol. 73, no. 3, pp. 472-475. https://doi.org/10.1021/np9005647
Fotso S, Santosa DA, Saraswati R, Yang J, Mahmud T, Zabriskie M et al. Modified phenazines from an indonesian streptomyces sp. Journal of Natural Products. 2010 Mar 26;73(3):472-475. https://doi.org/10.1021/np9005647
Fotso, Serge ; Santosa, Dwi Andreas ; Saraswati, Rasti ; Yang, Jongtae ; Mahmud, Taifo ; Zabriskie, Mark ; Proteau, Philip J. / Modified phenazines from an indonesian streptomyces sp. In: Journal of Natural Products. 2010 ; Vol. 73, No. 3. pp. 472-475.
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