Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors

Edward Neuwelt, S. I. Rapoport

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Inadequate drug delivery to the brain, caused by an intact or partially intact blood-brain barrier (BBB), probably accounts for poor therapeutic responsiveness to cytoreductive drugs by malignant metastatic and primary brain tumors. Drug delivery can be enhanced in normal brains and brains with tumors by administering drugs into the carotid of vertebral circulation after osmotic opening of the BBB. The osmotic procedure in humans involves infusion into the carotid or vertebral arteries of a 25% mannitol solution for 30 s. The procedure is reversible, can be accomplished without long-term neurological deficits, and can be monitored in dogs and humans by means of enhanced computerized tomography. Osmotic BBB disruption, when combined with multiple drug administration, has proved effective in treating brain tumors in a small number of clinical cases.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalFederation Proceedings
Volume43
Issue number2
StatePublished - 1984

Fingerprint

Blood-Brain Barrier
Brain Neoplasms
Drug Therapy
Pharmaceutical Preparations
Vertebral Artery
Brain
Mannitol
Carotid Arteries
Tomography
Dogs
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors. / Neuwelt, Edward; Rapoport, S. I.

In: Federation Proceedings, Vol. 43, No. 2, 1984, p. 214-219.

Research output: Contribution to journalArticle

@article{6493d14f8eec4a1db31734aa86f5133c,
title = "Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors",
abstract = "Inadequate drug delivery to the brain, caused by an intact or partially intact blood-brain barrier (BBB), probably accounts for poor therapeutic responsiveness to cytoreductive drugs by malignant metastatic and primary brain tumors. Drug delivery can be enhanced in normal brains and brains with tumors by administering drugs into the carotid of vertebral circulation after osmotic opening of the BBB. The osmotic procedure in humans involves infusion into the carotid or vertebral arteries of a 25{\%} mannitol solution for 30 s. The procedure is reversible, can be accomplished without long-term neurological deficits, and can be monitored in dogs and humans by means of enhanced computerized tomography. Osmotic BBB disruption, when combined with multiple drug administration, has proved effective in treating brain tumors in a small number of clinical cases.",
author = "Edward Neuwelt and Rapoport, {S. I.}",
year = "1984",
language = "English (US)",
volume = "43",
pages = "214--219",
journal = "Federation Proceedings",
issn = "0014-9446",
number = "2",

}

TY - JOUR

T1 - Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors

AU - Neuwelt, Edward

AU - Rapoport, S. I.

PY - 1984

Y1 - 1984

N2 - Inadequate drug delivery to the brain, caused by an intact or partially intact blood-brain barrier (BBB), probably accounts for poor therapeutic responsiveness to cytoreductive drugs by malignant metastatic and primary brain tumors. Drug delivery can be enhanced in normal brains and brains with tumors by administering drugs into the carotid of vertebral circulation after osmotic opening of the BBB. The osmotic procedure in humans involves infusion into the carotid or vertebral arteries of a 25% mannitol solution for 30 s. The procedure is reversible, can be accomplished without long-term neurological deficits, and can be monitored in dogs and humans by means of enhanced computerized tomography. Osmotic BBB disruption, when combined with multiple drug administration, has proved effective in treating brain tumors in a small number of clinical cases.

AB - Inadequate drug delivery to the brain, caused by an intact or partially intact blood-brain barrier (BBB), probably accounts for poor therapeutic responsiveness to cytoreductive drugs by malignant metastatic and primary brain tumors. Drug delivery can be enhanced in normal brains and brains with tumors by administering drugs into the carotid of vertebral circulation after osmotic opening of the BBB. The osmotic procedure in humans involves infusion into the carotid or vertebral arteries of a 25% mannitol solution for 30 s. The procedure is reversible, can be accomplished without long-term neurological deficits, and can be monitored in dogs and humans by means of enhanced computerized tomography. Osmotic BBB disruption, when combined with multiple drug administration, has proved effective in treating brain tumors in a small number of clinical cases.

UR - http://www.scopus.com/inward/record.url?scp=0021346836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021346836&partnerID=8YFLogxK

M3 - Article

C2 - 6692941

AN - SCOPUS:0021346836

VL - 43

SP - 214

EP - 219

JO - Federation Proceedings

JF - Federation Proceedings

SN - 0014-9446

IS - 2

ER -