Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors

E. A. Neuwelt, S. I. Rapoport

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Inadequate drug delivery to the brain, caused by an intact or partially intact blood-brain barrier (BBB), probably accounts for poor therapeutic responsiveness to cytoreductive drugs by malignant metastatic and primary brain tumors. Drug delivery can be enhanced in normal brains and brains with tumors by administering drugs into the carotid of vertebral circulation after osmotic opening of the BBB. The osmotic procedure in humans involves infusion into the carotid or vertebral arteries of a 25% mannitol solution for 30 s. The procedure is reversible, can be accomplished without long-term neurological deficits, and can be monitored in dogs and humans by means of enhanced computerized tomography. Osmotic BBB disruption, when combined with multiple drug administration, has proved effective in treating brain tumors in a small number of clinical cases.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalFederation Proceedings
Issue number2
StatePublished - 1984

ASJC Scopus subject areas

  • Medicine(all)


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