Modification of lipid a reduces endotoxin-induced Eye effects

James (Jim) Rosenbaum, L. Langlois, H. Enkel, J. A K Wolfram

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intravenous endotoxin produces an acute toxic ocular reaction in rabbits. The core component of endotoxin, lipid A, can be modified by acid hydrolysis. This results in a detoxified ST that is relatively ineffective in inducing fever or lethal effects but which retains activity as a mitosen or as a cofaotor in inducing tumor necrosis. We report that detoxified endotoxin was relatively ineffective in inducing iris hypereuia, increased ocular vascular permeability, a rise in aqueous humor prostaglandin E2, or the Ceneration of aqueous humor neutrophil chemotactic activity. Chemotaotic activity was not increased in aqueous humor even though detoxified endotoxin effectively generated chemotactic activity from serum in vitro. These observations indicate the critical role of lipid A structure in producing ET-induced ocular effects and show that the ability of ET to act as a mitogen, induce turaor necrosis, or generate serum chemotactic activity can be dissociated from its ocular toxicity.

Original languageEnglish (US)
Pages (from-to)707-710
Number of pages4
JournalCurrent Eye Research
Volume4
Issue number6
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Endotoxins
Aqueous Humor
Lipids
Lipid A
Necrosis
Poisons
Capillary Permeability
Iris
Serum
Mitogens
Dinoprostone
Neutrophils
Hydrolysis
Fever
Rabbits
Acids
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Modification of lipid a reduces endotoxin-induced Eye effects. / Rosenbaum, James (Jim); Langlois, L.; Enkel, H.; Wolfram, J. A K.

In: Current Eye Research, Vol. 4, No. 6, 1985, p. 707-710.

Research output: Contribution to journalArticle

Rosenbaum, James (Jim) ; Langlois, L. ; Enkel, H. ; Wolfram, J. A K. / Modification of lipid a reduces endotoxin-induced Eye effects. In: Current Eye Research. 1985 ; Vol. 4, No. 6. pp. 707-710.
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