Modification of ethanol effects by bicuculline: genotype-dependent responses and inheritance

Tamara Phillips, Bruce C. Dudck

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Genetic influences on the interaction between ethanol (ETOH) and gamma-aminobutyric acid (GABA) neurotransmitter systems were eveluated with a survey of responses to coadministration of ETOH and a GABA antagonist, bicuculline, in a battery of inbred mouse strains. The selectively bred ETOH-sensitive Long-Sleep (LS) mice, the relatively ETOH-resistant Short-Sleep (SS) mice, and a genetically heterogeneous stock (GHS) were also evaluated. The effect of bicuculline on ETOH-induced sedation, hypothermia, and blood ethanol content upon recovery from sedation was assessed. Inheritance of these responses was also examined using F1 hybrids. The effect of bicuculline on ETOH-produced narcosis varied widely among stocks and included antagonism, potentiation, and no effect. Changes in ETOH-induced narcosis produced by bicuculline were accompanied by changes in blood ethanol concentrations consistent with an hypothesis of altered central nervous system sensitivity to ETOH. Knowledge of a strain's seizure susceptibility to the GABA antagonist or of its sensitivity to the hypnotic effects of ETOH were of no predictive value in estimating the outcome of coadministration studies, suggesting at least partially separate genetic influences on each phenotype. In cross-breeding studies there was commonly dominance toward a profile of bicuculline antagonism of ETOH narcosis but different patterns of dominance were observed for seizure susceptibility, again inicating separate genetic control. The results suggest considerable complexity of GABAergic involvement in genotype-dependent ETOH sensitivity.

Original languageEnglish (US)
Pages (from-to)549-555
Number of pages7
JournalPsychopharmacology
Volume98
Issue number4
DOIs
StatePublished - Aug 1989
Externally publishedYes

Fingerprint

Bicuculline
Ethanol
Stupor
Genotype
GABA Antagonists
Sleep
Seizures
Induced Hypothermia
Inbred Strains Mice
Hypnotics and Sedatives
gamma-Aminobutyric Acid
Breeding
Neurotransmitter Agents
Central Nervous System
Outcome Assessment (Health Care)
Phenotype

Keywords

  • Bicuculline
  • Ethanol (ETOH)
  • GABA
  • Genetics
  • Sedation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Modification of ethanol effects by bicuculline : genotype-dependent responses and inheritance. / Phillips, Tamara; Dudck, Bruce C.

In: Psychopharmacology, Vol. 98, No. 4, 08.1989, p. 549-555.

Research output: Contribution to journalArticle

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