Moderate hypoxia suppresses exercise-induced procoagulant changes

Thomas Deloughery, Deborah G. Robertson, Cristina A. Smith, David Sauer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hypoxia has been implicated as a stimulant of coagulation. As exertion is known to affect haemostasis, we sought to control for this by using a standardized protocol Subjects were exercised both at room air and at 12% oxygen. Exercise produced an increase in procoagulant factors, which was reduced with hypoxic exercise. Room air exercise increased fibrinolytic markers. Hypoxic exercise did not affect the increase in tissue plasminogen activator, but decreased the increase in plasminogen activator inhibitor-1 expression. Thus, it appears that hypoxia may exert an antithrombotic effect by both damping exercise-induced procoagulant changes and stimulating fibrinolysis.

Original languageEnglish (US)
Pages (from-to)369-372
Number of pages4
JournalBritish Journal of Haematology
Volume125
Issue number3
DOIs
StatePublished - May 2004

Fingerprint

Air
Plasminogen Activator Inhibitor 1
Fibrinolysis
Tissue Plasminogen Activator
Hemostasis
Oxygen
Hypoxia

Keywords

  • Altitude sickness
  • Coagulation
  • Exercise
  • Hypoxia

ASJC Scopus subject areas

  • Hematology

Cite this

Moderate hypoxia suppresses exercise-induced procoagulant changes. / Deloughery, Thomas; Robertson, Deborah G.; Smith, Cristina A.; Sauer, David.

In: British Journal of Haematology, Vol. 125, No. 3, 05.2004, p. 369-372.

Research output: Contribution to journalArticle

Deloughery, Thomas ; Robertson, Deborah G. ; Smith, Cristina A. ; Sauer, David. / Moderate hypoxia suppresses exercise-induced procoagulant changes. In: British Journal of Haematology. 2004 ; Vol. 125, No. 3. pp. 369-372.
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