Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques

I. Messaoudi, Mark Asquith, F. Engelmann, Byung Park, M. Brown, A. Rau, J. Shaw, Kathleen (Kathy) Grant

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have recently shown that chronic alcohol consumption in a rhesus macaque model of ethanol self-administration significantly modulates the serum cytokine profile. In this study, we extended these observations by investigating the impact of chronic ethanol exposure on the immune response to Modified Vaccinia Ankara (MVA). All animals were vaccinated with MVA before ethanol exposure to ethanol and then again after 7 months of 22. h/day of "open-access" drinking of 4% (w/v) ethanol. Our results indicate that animals whose blood ethanol concentration (BEC) chronically exceeded 80. mg/dl had lower CD4 and CD8 T cell proliferation as well as IgG responses following MVA booster than control animals. In contrast, relatively moderate drinkers whose BEC remained below 80. mg/ml exhibited more robust MVA-specific IgG and CD8 T cell responses than controls. To begin to uncover mechanisms underlying the differences in MVA-specific responses between the three groups, we analyzed plasma cytokine levels and microRNA expression in peripheral blood mononuclear cells following MVA booster. Our findings suggest that moderate ethanol consumption results in higher levels of antiviral cytokines and an expression profile of microRNAs linked to CD8 T cell differentiation. In summary, moderate alcohol consumption enhances recall vaccine responses, whereas chronic alcohol intoxication suppresses this response.

Original languageEnglish (US)
Pages (from-to)54-61
Number of pages8
JournalVaccine
Volume32
Issue number1
DOIs
StatePublished - Dec 17 2013

Fingerprint

Macaca mulatta
Vaccinia
Alcohol Drinking
Vaccinium
Ethanol
Vaccines
ethanol
vaccines
cytokines
T-lymphocytes
Cytokines
MicroRNAs
T-Lymphocytes
microRNA
Immunoglobulin G
Alcoholic Intoxication
animals
days open
Self Administration
alcohol drinking

Keywords

  • Antibody
  • Cytokine
  • Ethanol
  • Macaque
  • MicroRNA
  • MVA
  • T cell
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques. / Messaoudi, I.; Asquith, Mark; Engelmann, F.; Park, Byung; Brown, M.; Rau, A.; Shaw, J.; Grant, Kathleen (Kathy).

In: Vaccine, Vol. 32, No. 1, 17.12.2013, p. 54-61.

Research output: Contribution to journalArticle

Messaoudi, I. ; Asquith, Mark ; Engelmann, F. ; Park, Byung ; Brown, M. ; Rau, A. ; Shaw, J. ; Grant, Kathleen (Kathy). / Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques. In: Vaccine. 2013 ; Vol. 32, No. 1. pp. 54-61.
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