Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Ellen M. Langer, Brittany L. Allen-Petersen, Shelby M. King, Nicholas D. Kendsersky, Megan A. Turnidge, Genevra M. Kuziel, Rachelle Riggers, Ravi Samatham, Taylor S. Amery, Steven Jacques, Brett C. Sheppard, James E. Korkola, John L. Muschler, Guillaume Thibault, Young Hwan Chang, Joe W. Gray, Sharon C. Presnell, Deborah G. Nguyen, Rosalie C. Sears

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Langer et al. use three-dimensional bioprinting to incorporate multiple cell types, including patient-derived cells, into scaffold-free in vitro tumor tissues. They show that cells within these tissues self-organize, secrete extracellular matrix factors, and respond to extrinsic signals and that multiple tumorigenic phenotypes can be assessed simultaneously.

Original languageEnglish (US)
Pages (from-to)608-623.e6
JournalCell Reports
Issue number3
StatePublished - Jan 15 2019


  • 3D tumor models
  • breast cancer
  • pancreatic cancer
  • three-dimensional bioprinting
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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