Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Ellen M. Langer, Brittany L. Allen-Petersen, Shelby M. King, Nicholas D. Kendsersky, Megan A. Turnidge, Genevra M. Kuziel, Rachelle Riggers, Ravi Samatham, Taylor S. Amery, Steven Jacques, Brett Sheppard, James Korkola, John Muschler, Guillaume Thibault, Young Hwan Chang, Joe Gray, Sharon C. Presnell, Deborah G. Nguyen, Rosalie Sears

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Langer et al. use three-dimensional bioprinting to incorporate multiple cell types, including patient-derived cells, into scaffold-free in vitro tumor tissues. They show that cells within these tissues self-organize, secrete extracellular matrix factors, and respond to extrinsic signals and that multiple tumorigenic phenotypes can be assessed simultaneously.

Original languageEnglish (US)
Pages (from-to)608-623.e6
JournalCell Reports
Volume26
Issue number3
DOIs
StatePublished - Jan 15 2019

Fingerprint

Bioprinting
Tumors
Tissue
Phenotype
Scaffolds
Neoplasms
Extracellular Matrix
In Vitro Techniques

Keywords

  • 3D tumor models
  • breast cancer
  • pancreatic cancer
  • three-dimensional bioprinting
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Langer, E. M., Allen-Petersen, B. L., King, S. M., Kendsersky, N. D., Turnidge, M. A., Kuziel, G. M., ... Sears, R. (2019). Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. Cell Reports, 26(3), 608-623.e6. https://doi.org/10.1016/j.celrep.2018.12.090

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. / Langer, Ellen M.; Allen-Petersen, Brittany L.; King, Shelby M.; Kendsersky, Nicholas D.; Turnidge, Megan A.; Kuziel, Genevra M.; Riggers, Rachelle; Samatham, Ravi; Amery, Taylor S.; Jacques, Steven; Sheppard, Brett; Korkola, James; Muschler, John; Thibault, Guillaume; Chang, Young Hwan; Gray, Joe; Presnell, Sharon C.; Nguyen, Deborah G.; Sears, Rosalie.

In: Cell Reports, Vol. 26, No. 3, 15.01.2019, p. 608-623.e6.

Research output: Contribution to journalArticle

Langer, EM, Allen-Petersen, BL, King, SM, Kendsersky, ND, Turnidge, MA, Kuziel, GM, Riggers, R, Samatham, R, Amery, TS, Jacques, S, Sheppard, B, Korkola, J, Muschler, J, Thibault, G, Chang, YH, Gray, J, Presnell, SC, Nguyen, DG & Sears, R 2019, 'Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting', Cell Reports, vol. 26, no. 3, pp. 608-623.e6. https://doi.org/10.1016/j.celrep.2018.12.090
Langer EM, Allen-Petersen BL, King SM, Kendsersky ND, Turnidge MA, Kuziel GM et al. Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. Cell Reports. 2019 Jan 15;26(3):608-623.e6. https://doi.org/10.1016/j.celrep.2018.12.090
Langer, Ellen M. ; Allen-Petersen, Brittany L. ; King, Shelby M. ; Kendsersky, Nicholas D. ; Turnidge, Megan A. ; Kuziel, Genevra M. ; Riggers, Rachelle ; Samatham, Ravi ; Amery, Taylor S. ; Jacques, Steven ; Sheppard, Brett ; Korkola, James ; Muschler, John ; Thibault, Guillaume ; Chang, Young Hwan ; Gray, Joe ; Presnell, Sharon C. ; Nguyen, Deborah G. ; Sears, Rosalie. / Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. In: Cell Reports. 2019 ; Vol. 26, No. 3. pp. 608-623.e6.
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