Abstract
Langer et al. use three-dimensional bioprinting to incorporate multiple cell types, including patient-derived cells, into scaffold-free in vitro tumor tissues. They show that cells within these tissues self-organize, secrete extracellular matrix factors, and respond to extrinsic signals and that multiple tumorigenic phenotypes can be assessed simultaneously.
Original language | English (US) |
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Pages (from-to) | 608-623.e6 |
Journal | Cell Reports |
Volume | 26 |
Issue number | 3 |
DOIs | |
State | Published - Jan 15 2019 |
Keywords
- 3D tumor models
- breast cancer
- pancreatic cancer
- three-dimensional bioprinting
- tumor microenvironment
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology