Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

Ellen M. Langer, Brittany L. Allen-Petersen, Shelby M. King, Nicholas D. Kendsersky, Megan A. Turnidge, Genevra M. Kuziel, Rachelle Riggers, Ravi Samatham, Taylor S. Amery, Steven L. Jacques, Brett C. Sheppard, James E. Korkola, John L. Muschler, Guillaume Thibault, Young Hwan Chang, Joe W. Gray, Sharon C. Presnell, Deborah G. Nguyen, Rosalie C. Sears

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Langer et al. use three-dimensional bioprinting to incorporate multiple cell types, including patient-derived cells, into scaffold-free in vitro tumor tissues. They show that cells within these tissues self-organize, secrete extracellular matrix factors, and respond to extrinsic signals and that multiple tumorigenic phenotypes can be assessed simultaneously.

Original languageEnglish (US)
Pages (from-to)608-623.e6
JournalCell Reports
Volume26
Issue number3
DOIs
StatePublished - Jan 15 2019

Keywords

  • 3D tumor models
  • breast cancer
  • pancreatic cancer
  • three-dimensional bioprinting
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting'. Together they form a unique fingerprint.

  • Cite this

    Langer, E. M., Allen-Petersen, B. L., King, S. M., Kendsersky, N. D., Turnidge, M. A., Kuziel, G. M., Riggers, R., Samatham, R., Amery, T. S., Jacques, S. L., Sheppard, B. C., Korkola, J. E., Muschler, J. L., Thibault, G., Chang, Y. H., Gray, J. W., Presnell, S. C., Nguyen, D. G., & Sears, R. C. (2019). Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting. Cell Reports, 26(3), 608-623.e6. https://doi.org/10.1016/j.celrep.2018.12.090