Modeling the myocardial dilution curve of a pure intravascular indicator

J. S. Lee, J. Karch, A. R. Jayaweera, Jonathan Lindner, L. P. Lee, D. M. Skyba, Sanjiv Kaul

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The dispersion and dilution of contrast medium through the myocardial vasculature is examined first with a serial model comprised of arterial, capillary, and venous components in series to determine their time- concentration curves (TCC) and the myocardial dilution curve (MDC). Analysis of general characteristics shows that the first moment of the MDC, adjusted for that of the aortic TCC and mean transit time (MTT) from the aorta to the first intramyocardial artery, is one-half the MTT of the myocardial vasculature and that the ratio of the area of the MDC and aortic TCC is the fractional myocardial blood volume (MBV). The use of known coronary vascular morphometry and a set of transport functions indicates that the temporal change in MDC is primarily controlled by the MTT. An analysis of several models with heterogeneous flow distributions justifies the procedures to calculate MTT and MBV from the measured MDC. Compared with previously described models, the present model is more general and provides a physical basis for the effects of flow dispersion and heterogeneity on the characteristics of the MDC.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume273
Issue number4 42-4
StatePublished - 1997
Externally publishedYes

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Blood Volume
Contrast Media
Blood Vessels
Aorta
Arteries

Keywords

  • Blood volume
  • Intravascular indicator
  • Mean transit time
  • Myocardial blood flow

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Modeling the myocardial dilution curve of a pure intravascular indicator. / Lee, J. S.; Karch, J.; Jayaweera, A. R.; Lindner, Jonathan; Lee, L. P.; Skyba, D. M.; Kaul, Sanjiv.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 273, No. 4 42-4, 1997.

Research output: Contribution to journalArticle

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AU - Karch, J.

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AU - Skyba, D. M.

AU - Kaul, Sanjiv

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AB - The dispersion and dilution of contrast medium through the myocardial vasculature is examined first with a serial model comprised of arterial, capillary, and venous components in series to determine their time- concentration curves (TCC) and the myocardial dilution curve (MDC). Analysis of general characteristics shows that the first moment of the MDC, adjusted for that of the aortic TCC and mean transit time (MTT) from the aorta to the first intramyocardial artery, is one-half the MTT of the myocardial vasculature and that the ratio of the area of the MDC and aortic TCC is the fractional myocardial blood volume (MBV). The use of known coronary vascular morphometry and a set of transport functions indicates that the temporal change in MDC is primarily controlled by the MTT. An analysis of several models with heterogeneous flow distributions justifies the procedures to calculate MTT and MBV from the measured MDC. Compared with previously described models, the present model is more general and provides a physical basis for the effects of flow dispersion and heterogeneity on the characteristics of the MDC.

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